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Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients

Abstract

The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate, response rate and response rate within 4 weeks using the cochrane review manager. We observed a significant association of the s/s variant of 5-HTTLPR with remission rate (P<0.0001) and both s/s and s/l variants with response rate (P=0.0002). Response rate within 4 weeks was associated in both models (P=0.003–P<0.00001). This effect is quite robust to ethnic differences although a significant heterogeneity is present in Asian samples.

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Serretti, A., Kato, M., De Ronchi, D. et al. Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry 12, 247–257 (2007). https://doi.org/10.1038/sj.mp.4001926

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  • DOI: https://doi.org/10.1038/sj.mp.4001926

Keywords

  • depression
  • meta-analysis
  • 5-HTTLPR
  • polymorphism
  • treatment response
  • SSRI

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