Localization of SNPs in the CHRNB2 gene

Location of single-nucleotide polymorphisms (SNPs) in the CHRNB2 gene and its vicinity that were included in an analysis of the association of this and other nicotinic cholinergic receptor genes with smoking initiation and nicotine dependence among young women. Linkage disequilibrium (LD) between SNPs (D′) is shown in the bottom portion of the figure, as computed by the Haploview 3.12 program. The LD blocks are defined by the confidence interval (CI) algorithm. Haplotype-tagging SNPs are marked with green asterisks. A CACTA haplotype made up of the five haplotype-tagging SNPs exerted a protective effect against smoking initiation, showing excess representation in non-initiators (frequency in smoking initiators=0.13, in non-initiators=0.19; P=0.036). In logistic regression analysis, non-carriers of the CHRNB2 CACTA haplotype had an odds ratio of 2.02 for smoking initiation (95% CI 1.10–3.70, P=0.023). For more information on this topic, please refer to article by Greenbaum et al. on pages 312–322.

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Greenbaum, L., Kanyas, K., Karni, O. et al. Localization of SNPs in the CHRNB2 gene. Mol Psychiatry 11, 223 (2006). https://doi.org/10.1038/sj.mp.4001810

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