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Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR

Molecular Psychiatry volume 11, pages 649–662 (2006)Cite this article

Abstract

An insertion/deletion polymorphism in the SERT linked promoter region (SERTLPR), previously reported to regulate mRNA expression in vitro, has been associated with mental disorders and response to psychotropic drugs. Contradictory evidence, however, has raised questions about the role of SERTLPR in regulating mRNA expression in vivo. We have used analysis of allelic expression imbalance (AEI) of SERT mRNA to assess quantitatively the contribution of SERTLPR to mRNA expression in human post-mortem pons tissue sections containing serotonergic neurons of the dorsal and median raphe nuclei. Any difference in the expression of one allele over the other indicates the presence of cis-acting elements that differentially affect transcription and/or mRNA processing and turnover. Using a marker SNP in the 3′ untranslated region of SERT mRNA, statistically significant differences in allelic mRNA levels were detected in nine out of 29 samples heterozygous for the marker SNP. While the allelic expression differences were relatively small (15–25%), they could nevertheless be physiologically relevant. Although previous results had suggested that the long form of SERTLPR yields higher mRNA levels than the short form, we did not observe a correlation between SERTLPR and allelic expression ratios. Also in contrast to previous results, we found no correlation between SERTLPR and allelic expression ratios or SERT mRNA levels in B-lymphocytes. This study demonstrates that regulation of SERT mRNA is independent of SERTLPR, but could be associated with polymorphisms in partial linkage disequilibrium with SERTLPR.

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References

  1. Lucki I . The spectrum of behaviors influenced by serotonin. Biol Psychiatry 1998; 44: 151–162.

    Article  CAS  PubMed  Google Scholar 

  2. Ursin R . Serotonin and sleep. Sleep Med Rev 2002; 6: 55–69.

    Article  PubMed  Google Scholar 

  3. Gingrich JA, Ansorge MS, Merker R, Weisstaub N, Zhou M . New lessons from knockout mice: The role of serotonin during development and its possible contribution to the origins of neuropsychiatric disorders. CNS Spectrosc 2003; 8: 572–577.

    Article  Google Scholar 

  4. Swann AC . Neuroreceptor mechanisms of aggression and its treatment. J Clin Psychiatry 2003; 64 (Suppl 4): 26–35.

    CAS  PubMed  Google Scholar 

  5. Lieberman JA, Mailman RB, Duncan G, Sikich L, Chakos M, Nichols DE et al. Serotonergic basis of antipsychotic drug effects in schizophrenia. Biol Psychiatry 1998; 44: 1099–1117.

    Article  CAS  PubMed  Google Scholar 

  6. Roth BL, Hanizavareh SM, Blum AE . Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders. Psychopharmacology (Berl) 2004; 174: 17–24.

    Article  CAS  Google Scholar 

  7. Lesch KP, Zeng Y, Reif A, Gutknecht L . Anxiety-related traits in mice with modified genes of the serotonergic pathway. Eur J Pharmacol 2003; 480: 185–204.

    Article  CAS  PubMed  Google Scholar 

  8. Kaye WH, Frank GK, Bailer UF, Henry SE . Neurobiology of anorexia nervosa: clinical implications of alterations of the function of serotonin and other neuronal systems. Int J Eat Disord 2005; 37 (Suppl): S15–S19; discussion S20–S21.

    Article  PubMed  Google Scholar 

  9. Olausson P, Engel JA, Soderpalm B . Involvement of serotonin in nicotine dependence: processes relevant to positive and negative regulation of drug intake. Pharmacol Biochem Behav 2002; 71: 757–771.

    Article  CAS  PubMed  Google Scholar 

  10. Higgins GA, Fletcher PJ . Serotonin and drug reward: focus on 5-HT2C receptors. Eur J Pharmacol 2003; 480: 151–162.

    Article  CAS  PubMed  Google Scholar 

  11. Oroszi G, Goldman D . Alcoholism: genes and mechanisms. Pharmacogenomics 2004; 5: 1037–1048.

    Article  CAS  PubMed  Google Scholar 

  12. Kreek MJ, Bart G, Lilly C, LaForge KS, Nielsen DA . Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol Rev 2005; 57: 1–26.

    Article  CAS  PubMed  Google Scholar 

  13. Wong ML, Licinio J . Research and treatment approaches to depression. Nat Rev Neurosci 2001; 2: 343–351.

    Article  CAS  PubMed  Google Scholar 

  14. Nemeroff CB, Owens MJ . Treatment of mood disorders. Nat Neurosci 2002; 5 (Suppl): 1068–1070.

    Article  CAS  PubMed  Google Scholar 

  15. Arango V, Underwood MD, Mann JJ . Serotonin brain circuits involved in major depression and suicide. Prog Brain Res 2002; 136: 443–453.

    Article  CAS  PubMed  Google Scholar 

  16. Neumeister A, Young T, Stastny J . Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter. Psychopharmacology (Berl) 2004; 174: 512–524.

    Article  CAS  Google Scholar 

  17. Joiner Jr TE, Brown JS, Wingate LR . The psychology and neurobiology of suicidal behavior. Annu Rev Psychol 2005; 56: 287–314.

    Article  PubMed  Google Scholar 

  18. Rudnick G, Clark J . From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. Biochim Biophys Acta 1993; 1144: 249–263.

    Article  CAS  PubMed  Google Scholar 

  19. Norregaard L, Gether U . The monoamine neurotransmitter transporters: structure, conformational changes and molecular gating. Curr Opin Drug Discov Devel 2001; 4: 591–601.

    CAS  PubMed  Google Scholar 

  20. Hornung JP . The human raphe nuclei and the serotonergic system. J Chem Neuroanat 2003; 26: 331–343.

    Article  CAS  PubMed  Google Scholar 

  21. Roman DL, Walline CC, Rodriguez GJ, Barker EL . Interactions of antidepressants with the serotonin transporter: a contemporary molecular analysis. Eur J Pharmacol 2003; 479: 53–63.

    Article  CAS  PubMed  Google Scholar 

  22. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS et al. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 1993; 90: 2542–2546.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL et al. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994; 95: 157–162.

    Article  CAS  PubMed  Google Scholar 

  24. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996; 274: 1527–1531.

    Article  CAS  PubMed  Google Scholar 

  25. Heils A, Teufel A, Petri S, Stober G, Riederer P et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996; 66: 2621–2624.

    Article  CAS  PubMed  Google Scholar 

  26. Sakai K, Nakamura M, Ueno S, Sano A, Sakai N, Shirai Y et al. The silencer activity of the novel human serotonin transporter linked polymorphic regions. Neurosci Lett 2002; 327: 13–16.

    Article  CAS  PubMed  Google Scholar 

  27. MacKenzie A, Quinn J . A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci USA 1999; 96: 15251–15255.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Bradley CC, Blakely RD . Alternative splicing of the human serotonin transporter gene. J Neurochem 1997; 69: 1356–1367.

    Article  CAS  PubMed  Google Scholar 

  29. Ozsarac N, Santha E, Hoffman BJ . Alternative non-coding exons support serotonin transporter mRNA expression in the brain and gut. J Neurochem 2002; 82: 336–344.

    Article  CAS  PubMed  Google Scholar 

  30. Battersby S, Ogilvie AD, Blackwood DH, Shen S, Muqit MM, Muir WJ et al. Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3′ untranslated region of the human serotonin transporter gene. J Neurochem 1999; 72: 1384–1388.

    Article  CAS  PubMed  Google Scholar 

  31. Murphy DL, Lerner A, Rudnick G, Lesch KP . Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol Interv 2004; 4: 109–123.

    Article  CAS  PubMed  Google Scholar 

  32. Heils A, Teufel A, Petri S, Seemann M, Bengel D, Balling U et al. Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm Gen Sect 1995; 102: 247–254.

    Article  CAS  PubMed  Google Scholar 

  33. Mortensen OV, Thomassen M, Larsen MB, Whittemore SR, Wiborg O . Functional analysis of a novel human serotonin transporter gene promoter in immortalized raphe cells. Brain Res Mol Brain Res 1999; 68: 141–148.

    Article  CAS  PubMed  Google Scholar 

  34. Greenberg BD, Tolliver TJ, Huang SJ, Li Q, Bengel D, Murphy DL . Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am J Med Genet 1999; 88: 83–87.

    Article  CAS  PubMed  Google Scholar 

  35. Nobile M, Begni B, Giorda R, Frigerio A, Marino C, Molteni M et al. Effects of serotonin transporter promoter genotype on platelet serotonin transporter functionality in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry 1999; 38: 1396–1402.

    Article  CAS  PubMed  Google Scholar 

  36. Stoltenberg SF, Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Zucker RA et al. Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism. Am J Med Genet 2002; 114: 230–234.

    Article  PubMed  Google Scholar 

  37. Hanna GL, Himle JA, Curtis GC, Koram DQ, Veenstra-VanderWeele J, Leventhal BL et al. Serotonin transporter and seasonal variation in blood serotonin in families with obsessive-compulsive disorder. Neuropsychopharmacology 1998; 18: 102–111.

    Article  CAS  PubMed  Google Scholar 

  38. Little KY, McLaughlin DP, Zhang L, Livermore CS, Dalack GW, McFinton PR et al. Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 1998; 155: 207–213.

    Article  CAS  PubMed  Google Scholar 

  39. Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 2000; 47: 643–649.

    Article  CAS  PubMed  Google Scholar 

  40. Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, Jernej B et al. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry 2004; 55: 1090–1094.

    Article  CAS  PubMed  Google Scholar 

  41. Willeit M, Stastny J, Pirker W, Praschak-Rieder N, Neumeister A, Asenbaum S et al. No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism. Biol Psychiatry 2001; 50: 8–12.

    Article  CAS  PubMed  Google Scholar 

  42. Shioe K, Ichimiya T, Suhara T, Takano A, Sudo Y, Yasuno F et al. No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET. Synapse 2003; 48: 184–188.

    Article  CAS  PubMed  Google Scholar 

  43. McLaughlin DP, Little KY, Lopez JF, Watson SJ . Expression of serotonin transporter mRNA in human brainstem raphe nuclei. Neuropsychopharmacology 1996; 15: 523–529.

    Article  CAS  PubMed  Google Scholar 

  44. Yan H, Yuan W, Velculescu VE, Vogelstein B, Kinzler KW . Allelic variation in human gene expression. Science 2002; 297: 1143.

    Article  CAS  PubMed  Google Scholar 

  45. Pastinen T, Hudson TJ . Cis-acting regulatory variation in the human genome. Science 2004; 306: 647–650.

    Article  CAS  PubMed  Google Scholar 

  46. Pastinen T, Sladek R, Gurd S, Sammak A, Ge B, Lepage P et al. A survey of genetic and epigenetic variation affecting human gene expression. Physiol Genomics 2004; 184–193.

  47. Yan H, Zhou W . Allelic variations in gene expression. Curr Opin Oncol 2004; 16: 39–43.

    Article  PubMed  Google Scholar 

  48. Johnson AD, Wang D, Sadee W . Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics. Pharmacol Ther 2005; 106: 19–38.

    Article  CAS  PubMed  Google Scholar 

  49. Rockman MV, Wray GA . Abundant raw material for cis-regulatory evolution in humans. Mol Biol Evol 2002; 19: 1991–2004.

    Article  CAS  PubMed  Google Scholar 

  50. Bray NJ, Buckland PR, Owen MJ, O’Donovan MC . Cis-acting variation in the expression of a high proportion of genes in human brain. Hum Genet 2003; 113: 149–153.

    PubMed  Google Scholar 

  51. Pinsonneault J, Sadee W . Pharmacogenomics of multigenic diseases: sex-specific differences in disease and treatment outcome. AAPS Pharm Sci 2003; 5: E29.

    Article  Google Scholar 

  52. Zhang Y, Wang D, Johnson AD, Papp AC, Sadee W . Allelic expression imbalance of human mu opioid receptor (OPRM1) caused by variant A118G. J Biol Chem 2005; 280: 32618–32624.

    Article  CAS  PubMed  Google Scholar 

  53. Wang D, Johnson AD, Papp AC, Kroetz DL, Sadee W . Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability. Pharmacogenet Genomics 2005; 15: 693–704.

    Article  CAS  PubMed  Google Scholar 

  54. Okimoto R, Dodgson JB . Improved PCR amplification of multiple specific alleles (PAMSA) using internally mismatched primers. Biotechniques 1996; 21: 20–22, 24, 26.

    Article  CAS  PubMed  Google Scholar 

  55. Pinsonneault J, Nielsen CU, Sadee W . Genetic variants of the human H+/dipeptide transporter PEPT2: analysis of haplotype functions. J Pharmacol Exp Ther 2004; 311: 1088–1096.

    Article  CAS  PubMed  Google Scholar 

  56. Conroy J, Meally E, Kearney G, Fitzgerald M, Gill M, Gallagher L . Serotonin transporter gene and autism: a haplotype analysis in an Irish autistic population. Mol Psychiatry 2004; 9: 587–593.

    Article  CAS  PubMed  Google Scholar 

  57. The International HapMap Project. Nature 2003; 426: 789–796.

  58. Naylor L, Dean B, Pereira A, Mackinnon A, Kouzmenko A, Copolov D . No association between the serotonin transporter-linked promoter region polymorphism and either schizophrenia or density of the serotonin transporter in human hippocampus. Mol Med 1998; 4: 671–674.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Anguelova M, Benkelfat C, Turecki G . A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry 2003; 8: 574–591.

    Article  CAS  PubMed  Google Scholar 

  60. Fan JB, Sklar P . Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia. Mol Psychiatry 2005; 10: 928–938.

    Article  CAS  PubMed  Google Scholar 

  61. Lasky-Su JA, Faraone SV, Glatt SJ, Tsuang MT . Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet B Neuropsychiatr Genet 2005; 133: 110–115.

    Article  Google Scholar 

  62. Lotrich FE, Pollock BG . Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatr Genet 2004; 14: 121–129.

    Article  PubMed  Google Scholar 

  63. Sen S, Burmeister M, Ghosh D . Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet 2004; 127: 85–89.

    Article  Google Scholar 

  64. Cho HJ, Meira-Lima I, Cordeiro Q, Michelon L, Sham P, Vallada H . et al. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis. Mol Psychiatry 2005; 10: 771–781.

    Article  CAS  PubMed  Google Scholar 

  65. Munafo MR, Clark T, Flint J . Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Mol Psychiatry 2005; 10: 415–419.

    Article  CAS  PubMed  Google Scholar 

  66. Schinka JA, Busch RM, Robichaux-Keene N . A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 2004; 9: 197–202.

    Article  CAS  PubMed  Google Scholar 

  67. Anguelova M, Benkelfat C, Turecki G . A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003; 8: 646–653.

    Article  CAS  PubMed  Google Scholar 

  68. Lin PY, Tsai G . Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry 2004; 55: 1023–1030.

    Article  CAS  PubMed  Google Scholar 

  69. Heinz A, Jones DW, Gorey JG, Bennet A, Suomi SJ, Weinberger DR et al. Serotonin transporter availability correlates with alcohol intake in non-human primates. Mol Psychiatry 2003; 8: 231–234.

    Article  CAS  PubMed  Google Scholar 

  70. Feinn R, Nellissery M, Kranzler HR . Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 2005; 133: 79–84.

    Article  Google Scholar 

  71. Peters EJ, Slager SL, McGrath PJ, Knowles JA, Hamilton SP . Investigation of serotonin-related genes in antidepressant response. Mol Psychiatry 2004; 9: 879–889.

    Article  CAS  PubMed  Google Scholar 

  72. Serretti A, Benedetti F, Zanardi R, Smeraldi E . The influence of Serotonin Transporter Promoter Polymorphism (SERTPR) and other polymorphisms of the serotonin pathway on the efficacy of antidepressant treatments. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29: 1074–1084.

    Article  CAS  PubMed  Google Scholar 

  73. Lesch KP, Gutknecht L . Pharmacogenetics of the serotonin transporter. Prog Neuropsychopharmacol Biol Psychiatry 2005; 29: 1062–1073.

    Article  CAS  PubMed  Google Scholar 

  74. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297: 400–403.

    Article  CAS  PubMed  Google Scholar 

  75. Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF et al. A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 2005; 62: 146–152.

    Article  CAS  PubMed  Google Scholar 

  76. Bertolino A, Arciero G, Rubino V, Latorre V, De Candia M, Mazzola V et al. Variation of human amygdala response during threatening stimuli as a function of 5′HTTLPR genotype and personality style. Biol Psychiatry 2005; 57: 1517–1525.

    Article  CAS  PubMed  Google Scholar 

  77. Pezawas L, Meyer-Lindenberg A, Drabant EM, Verchinski BA, Munoz KE, Kolachana BS et al. 5-HTTLPR polymorphism impacts human cingulate–amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005; 8: 828–834.

    Article  CAS  PubMed  Google Scholar 

  78. Hahn MK, Blakely RD . Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. Pharmacogenomics J 2002; 2: 217–235.

    Article  CAS  PubMed  Google Scholar 

  79. Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J et al. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry 2003; 8: 895, 933–936.

    Article  Google Scholar 

  80. Sutcliffe JS, Delahanty RJ, Prasad HC, McCauley JL, Han Q, Jiang L et al. Allelic Heterogeneity at the Serotonin Transporter Locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Am J Hum Genet 2005; 77: 265–279.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Bray NJ, Buckland PR, Williams NM, Williams HJ, Norton N, Owen MJ et al. A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. Am J Hum Genet 2003; 73: 152–161.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  82. Murphy DL, Li Q, Engel S, Wichems C, Andrews A, Lesch KP et al. Genetic perspectives on the serotonin transporter. Brain Res Bull 2001; 56: 487–494.

    Article  CAS  PubMed  Google Scholar 

  83. Bennett AJ, Lesch KP, Heils A, Long JC, Lorenz JG, Shoaf SE et al. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol Psychiatry 2002; 7: 118–122.

    Article  CAS  PubMed  Google Scholar 

  84. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003; 301: 386–389.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by NIH research grants DA018744 (National Institute on Drug Abuse) and GM61390 (Pharmacogenetics Research Network, General Medical Sciences; UCSF Membrane Transporter Group) and by a grant from the Psychiatric Research Foundation, Columbus, Ohio. The data will be deposited into the Pharmacogenetics Research Network Knowledgebase at www.pharmgkb.org.

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  1. Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    J-E Lim, A Papp, J Pinsonneault, W Sadée & D Saffen

  2. Department of Psychiatry, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    W Sadée & D Saffen

  3. Program in Pharmacogenomics, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    A Papp, J Pinsonneault, W Sadée & D Saffen

  4. The Neuroscience Graduate Studies Program, College of Medicine and Public Health, The Ohio State University, Columbus, OH, USA

    J-E Lim, W Sadée & D Saffen

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Lim, JE., Papp, A., Pinsonneault, J. et al. Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR. Mol Psychiatry 11, 649–662 (2006). https://doi.org/10.1038/sj.mp.4001797

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