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Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations

Molecular Psychiatry volume 11, pages 479–487 (2006)Cite this article

Abstract

Recently, the nested genes G72 and G30 on chromosome 13q32–q33 have been implicated in the etiology of schizophrenia. We genotyped six single-nucleotide polymorphisms (SNPs: rs3916965, rs3916967, rs2391191, rs778294, rs779293 and rs3918342), which span approximately 82.5 kb in the region encompassing the G72/G30 genes in 1176 Han Chinese subjects (588 cases and 588 controls) and 365 Scottish subjects (183 cases and 182 controls). Significant association between an allele of marker rs778293 and schizophrenia was found in our Chinese samples (P=0.0013), and was replicated in the Scottish samples (P=0.022). LD analysis revealed that four SNPs between rs3916965 and rs778294 were in LD, called block I, and the two distal SNPs (rs778293 and rs3918342) constituted a block II in both the Chinese and Scottish samples. We selected one SNP from each block (rs778294 from block I and rs778293 from block II), and then analyzed the haplotypes. A significant difference was observed for the common haplotype GC in the Chinese sample (P=0.0145), and was replicated in the Scottish sample (P=0.003). On meta-analysis, we separately analyzed the studies in Asian and European populations because of significant heterogeneity in the homogeneity test. We found a statistically significant association between rs778293 and schizophrenia in Asian populations, but no difference was found between cases and controls in the European populations. Overall, our data give further support to the existing evidence that G72/G30 genes are involved in conferring susceptibility to schizophrenia.

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Acknowledgements

We are deeply grateful to all the families who participated in this study, as well as to the psychiatrists and mental health workers who helped us with the identification of the families. This work was supported by grants from the Ministry of Education, PRC, the national 973 and 863 Projects, the National Natural Science Foundation of China and the Shanghai Municipal Commission for Science and Technology.

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Authors and Affiliations

  1. Bio-X Center, Shanghai Jiao Tong University, Shanghai, People's Republic of China

    J Ma, W Qin, S W Duan & L He

  2. Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China

    J Ma, W Qin, X Y Wang, T W Guo, L Bian, X W Li, F G Zou & L He

  3. Huangshan Second People's Hospital, Anhui Province, People's Republic of China

    Y R Fang & J X Fang

  4. Shanghai Institute of Mental Health, Shanghai, People's Republic of China

    G Y Feng & N F Gu

  5. Department of Mental Health, University of Aberdeen, Medical School, Foresterhill, Aberdeen, UK

    D St Clair

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  1. J Ma
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Correspondence to W Qin.

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Ma, J., Qin, W., Wang, X. et al. Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations. Mol Psychiatry 11, 479–487 (2006). https://doi.org/10.1038/sj.mp.4001788

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  • DOI: https://doi.org/10.1038/sj.mp.4001788

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