Brain potential amplitude varies as a function of Borna disease virus-specific immune complexes in obsessive–compulsive disorder

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(a) Grand-average ERPs from left and right temporoparietal sites (P7/P8) showing a marked increase of N1 amplitude for group H. Mean amplitude (160–180 ms) at this electrode pair showed an overall group difference (F(2,21)=6.98; P<0.005) with post hoc tests (Scheffé) indicating differences between group H and controls (P<0.01), group H and group L (P<0.01), but no difference between group L and controls. (b) Source analysis (LORETA) for the grand average showed a prominent left temporoparietal source at 152 ms for group H subjects corresponding to Brodmann areas 19/37/39. Voxels in the region marked in black showed activity higher than 0.01 μA/mm2. (c) A statistical comparison of the individual source solutions (LORETA, time window 140–180 ms) of group H and control subjects revealed group differences in medial frontal and lateral temporo-occipital regions. The darker zones (encircled) represent those voxels for which t-values exceeded the threshold of significance (corrected for multiple comparisons). For more information on this topic, please see the article by Dietrich et al on pages 519–520.

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