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Evidence for linkage to chromosome 13q32 in an independent sample of schizophrenia families

Molecular Psychiatry volume 10, pages 429–431 (2005)Cite this article

SIR — Schizophrenia is a severe psychiatric disorder that affects 1% of the population worldwide. One promising avenue for understanding the pathophysiology of schizophrenia lies with identification of genes underlying schizophrenia risk or susceptibility. Linkage analysis has identified several candidate genomic regions, including chromosome 13q;1, 2, 3, 4 however, this region has not been replicated in all studies. Here, we report evidence for linkage to chromosome 13q32 in a sample of 39 affected sib-pairs (ASPs), obtained from the NIMH Genetics Initiative (26 ASPs)5 and the Western Psychiatric Institute and Clinic (13 ASPs).6

Ascertainment of schizophrenia sib-pairs has been previously described for both the NIMH sample5 and the Pittsburgh sample.6 We selected pedigrees for our linkage study if the pedigree contained an ASP and DNA from both parents. All pedigrees consistent with these criteria were selected. A total of 26 such pedigrees were available from the NIMH sample and 13 sib-pair pedigrees were available from the Pittsburgh sample (details of the linkage sample can be found in Table 1). These 39 families (164 subjects) were genotyped at marker D13S174, where peak linkage evidence was obtained in another study.3 Eight other markers flanking D13S174 were selected, covering 8 Mb (14 cM) of genomic sequence (markers are D13S793, D13S1271, D13S1284, D13S1323, D13S174, D13S888, D13S1256, D13S280, D13S1311). Multipoint linkage analysis was performed using the GENEHUNTER PLUS program (version 2.0).7, 8 The structure of families used in this analysis was largely homogenous (nuclear ASP families); therefore, the Spairs and Sall scoring functions of GENEHUNTER produced nearly identical results. Empiric P-values were determined by analyzing 10 000 simulated data sets as implemented by MERLIN software.9 The genetic map used for linkage analysis was according to Christian et al.10

Table 1 Sample used for linkage analysis
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Author notes

  1. J G Mulle and J A McDonough: These two authors contributed equally to this work.

Authors and Affiliations

  1. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA

    J G Mulle & A Chakravarti

  2. Oak Clinic for MS Research, Kent State University, Kent, OH, USA

    J A McDonough

  3. Western Psychiatric Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

    K V Chowdari & V Nimgaonkar

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  1. J G Mulle
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  2. J A McDonough
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  3. K V Chowdari
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  4. V Nimgaonkar
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  5. A Chakravarti
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Correspondence to A Chakravarti.

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Mulle, J., McDonough, J., Chowdari, K. et al. Evidence for linkage to chromosome 13q32 in an independent sample of schizophrenia families. Mol Psychiatry 10, 429–431 (2005). https://doi.org/10.1038/sj.mp.4001639

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