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Neuregulin 1: genetic support for schizophrenia subtypes

Molecular Psychiatry volume 9, pages 1061–1063 (2004)Cite this article

SIR—The deficit syndrome is a form of chronic schizophrenia characterized by enduring, idiopathic negative symptoms.1 Patients with this clinically distinct disease subtype have been suggested to differ in several biological aspects from patients with a more benign course with exacerbations and remissions.2 We hypothesized that part of the heterogeneity of disease course in schizophrenia is related to different contributing genetic factors. The neuregulin 1 gene (NRG1), assumed to be involved in glutamate neurotransmission and neurodevelopment, was recently reported to be associated with schizophrenia in several, but not all populations.3, 4, 5, 6, 7, 8, 9 We have investigated the association of NRG1 with schizophrenia in patients with and without the deficit syndrome.

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Authors and Affiliations

  1. Department of Psychiatry, University Medical Center, Utrecht, The Netherlands

    S C Bakker, M L C Hoogendoorn, J-P Selten & R S Kahn

  2. Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands

    W Verduijn

  3. Department of Biomedical Genetics, University Medical Center, Utrecht, The Netherlands

    P L Pearson & R J Sinke

Authors
  1. S C Bakker
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  2. M L C Hoogendoorn
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  3. J-P Selten
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  4. W Verduijn
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  5. P L Pearson
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  6. R J Sinke
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  7. R S Kahn
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Correspondence to S C Bakker.

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Bakker, S., Hoogendoorn, M., Selten, JP. et al. Neuregulin 1: genetic support for schizophrenia subtypes. Mol Psychiatry 9, 1061–1063 (2004). https://doi.org/10.1038/sj.mp.4001564

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