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Investigation of the ICAM-1 G241A and A469G gene polymorphisms in schizophrenia

Molecular Psychiatry volume 8, pages 257–258 (2003)Cite this article

SIR – Schizophrenia is a heterogenous disorder with a polygenic mode of transmission and additionally contributing environmental factors. The involvement of an immune process, characterized by a reduced activation of the cellular immune response has been proposed.1 Recent findings describe reduced serum levels of soluble intercellular adhesion molecule (sICAM-1) in unmedicated and medicated schizophrenic patients.2 ICAM-1 plays an important role in the activation of the cellular immune response.

The two ligands of ICAM-1 on lymphocytes and macrophages are lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (MAC-1).3 The human ICAM-1 gene, located on chromosome 19p13.3–p13.2, contains two important single-nucleotide polymorphisms (SNPs), both leading to an amino-acid change: The G→A SNP at position 241 coding for the Mac-1 binding domain and the A→G SNP at position 469 (LFA-1 binding site).4 Significant differences in allele frequencies of both polymorphisms have been detected in several diseases with immune-related pathophysiology including rheumatoid arthritis (RA) and insulin-dependent diabetes mellitus (IDDM).5,6

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References

  1. Schwarz MJ et al. Brain Behav Immun 2001; 15: 340–370.

  2. Schwarz MJ et al. Biol Psychiat 2000; 47: 29–33.

  3. Hogg N, Leitinger B . J Leukoc Biol 2001; 69: 893–898.

  4. Vora DK et al. Genomics 1994; 21: 473–477.

  5. Macchioni P et al. Clin Exp Rheumatol 2000; 18: 553–558.

  6. Nishimura M et al. Hum Immunol 2000; 61: 507–510.

  7. Almawi WY et al. J Clin Endocrinol Metab 1999; 84: 1497–1502.

  8. Gerli R et al. Trends Immunol 2001; 22: 72–77.

  9. Torrey EF, Yolken RH . Brain Behav Immun 2001; 15: 401–410.

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Authors and Affiliations

  1. Psychiatric Hospital, Ludwig-Maximilian University Munich, Germany

    M Riedel, H Krönig, M J Schwarz, R R Engel, C Sikorski, S Behrens, H-J Möller, M Ackenheil & N Müller

  2. Psychiatric Hospital, University of Bonn, Germany

    K-U Kühn

Authors
  1. M Riedel
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  2. H Krönig
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  3. M J Schwarz
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  4. R R Engel
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  5. C Sikorski
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  6. K-U Kühn
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  7. S Behrens
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  8. H-J Möller
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  9. M Ackenheil
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  10. N Müller
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Corresponding author

Correspondence to M J Schwarz.

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Supported by the Theodore and Vada Stanley Foundation.

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Riedel, M., Krönig, H., Schwarz, M. et al. Investigation of the ICAM-1 G241A and A469G gene polymorphisms in schizophrenia. Mol Psychiatry 8, 257–258 (2003). https://doi.org/10.1038/sj.mp.4001320

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  • DOI: https://doi.org/10.1038/sj.mp.4001320

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