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Linkage of schizophrenia with chromosome 1q loci in Taiwanese families

Molecular Psychiatry volume 8, pages 445–452 (2003)Cite this article

Abstract

A positive linkage of schizophrenia with chromosome 1q loci has been reported in Caucasian patients. This study was designed to evaluate the linkage of schizophrenia with markers of the 1q22–44 region in 52 Taiwanese families with at least two affected siblings. In the region 1q22–31 (17.8 cM), marker D1S1679 had a maximal proportion (0.57, P=0.03) of shared identity by descent (IBD) under a narrow phenotype (DSM-IV schizophrenia only). In the region 1q42–44 (26.8 cM), the marker D1S251, located near the breakpoint of a balanced translocation t (1;11) (q42.1;q14.3) segregated with schizophrenia, and also near the neurodevelopment-related ‘Disrupted in Schizophrenia 1’ gene, had a maximum NPL score of 1.73 (P=0.03) under the narrow phenotype model and 2.18 (P=0.01) under the broad phenotype model comprised of schizophrenia, schizoaffective disorder, and other nonaffective psychotic disorders as defined by DSM-IV criteria. The marker D1S2836 also had a maximal proportion (0.57, P=0.05) of shared IBD under the broad model. These findings may provide guidance for positional cloning studies on candidate genes in the 1q22–31 and 1q41–44 regions.

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Acknowledgements

This research was supported by grants from the National Health Research Institute (DOH83, 84, 85, 86, 87, 88-HR-306; NHRI-GT-EX89P825P; NHRI-GT-EX908825PP; and NHRI-EX91-9113PP) and partly by grants from National Taiwan University Hospital (NTUH-88-A0015) and the National Science Council, Taiwan (NSC-83-0412-B-170-MO2).

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Authors and Affiliations

  1. Department of Psychiatry, National Taiwan University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taipei, Taiwan

    H-G Hwu & C-M Liu

  2. Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan

    C S-J Fann

  3. Chianan Psychiatric Center, Tainan, Taiwan

    W-C Ou-Yang

  4. Taoyuan Psychiatric Center, Taoyuan, Taiwan

    S F-C Lee

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  1. H-G Hwu
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Hwu, HG., Liu, CM., Fann, CJ. et al. Linkage of schizophrenia with chromosome 1q loci in Taiwanese families. Mol Psychiatry 8, 445–452 (2003). https://doi.org/10.1038/sj.mp.4001235

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