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Mouse genetic models for prepulse inhibition: an early review

Molecular Psychiatry volume 7, pages 1039–1053 (2002)Cite this article

Abstract

Prepulse inhibition (PPI) is the phenomenon in which a weak prepulse stimulus attenuates the response to a subsequent startling stimulus. Patients with schizophrenia and some other neuropsychiatric disorders have impaired PPI. Impaired PPI in these patient populations is thought to reflect dysfunctional sensorimotor gating mechanisms. Recently, various inbred mouse strains and genetically modified mouse lines have been examined to investigate the potential genetic basis of sensorimotor gating. This review provides a synopsis of the use of mouse models to explore genetic and neurochemical influences on PPI. Studies describing the PPI responses of various inbred strains of mice, mice with genetic mutations, and mice treated with various drugs prior to July 2001 are reviewed. The continuous nature of the distribution of PPI responses among inbred strains of mice indicates that PPI is a polygenic trait. Findings from spontaneous and gene-targeted mutants suggest that mutant mice are important tools for dissecting and studying the role of single genes and their products, and chromosomal regions in regulating PPI. Pharmacological studies of PPI have typically confirmed effects in mice that are similar to those reported previously in rats, with some important exceptions. The use of mice to study PPI is increasing at a dramatic rate and is helping to increase our understanding of the biological basis for sensorimotor gating.

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Acknowledgements

These studies were supported by grants from the National Institute on Drug Abuse (DA02925) and the National Institute of Mental Health (MH61326, MH42228) and the Baylor College of Medicine Mental Retardation Center, FRAXA, and by the Veterans Affairs VISN 22 Mental Illness Research, Education, and Clinical Center. The authors thank Dr Kirsten Krebs-Thomson for assistance in the review of the relevant literature.

Author information

Author notes

  1. K L McIlwain

    Present address: Primal Inc, Seattle, WA, USA

Authors and Affiliations

  1. Department of Psychiatry, University of California San Diego, La Jolla, CA, USA

    M A Geyer

  2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

    K L McIlwain & R Paylor

  3. Division of Neuroscience, Baylor College of Medicine, Houston, TX, USA

    R Paylor

Authors
  1. M A Geyer
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  2. K L McIlwain
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  3. R Paylor
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Corresponding author

Correspondence to R Paylor.

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Geyer, M., McIlwain, K. & Paylor, R. Mouse genetic models for prepulse inhibition: an early review. Mol Psychiatry 7, 1039–1053 (2002). https://doi.org/10.1038/sj.mp.4001159

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  • DOI: https://doi.org/10.1038/sj.mp.4001159

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