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5-HT2A promoter polymorphism −1438G/A in children and adolescents with obsessive-compulsive disorders

Molecular Psychiatry volume 7, pages 1054–1057 (2002)Cite this article

Abstract

Positive association between obsessive compulsive disorder (OCD) and the A-allele of the 5-HT2A-receptor promoter polymorphism −1438G/A has recently been reported in adults. We performed an association analysis of this polymorphism in 55 children and adolescents with OCD and in 223 controls consisting of unrelated students. We detected statistically significant differences in genotype (P < 0.05) and allele frequencies (P < 0.05) between individuals with OCD and controls. In this, to our knowledge, first association study based on children and adolescents with OCD, we confirm an association of the A-allele of the 5-HT2A receptor gene with OCD.

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References

  1. DSM-IV. Diagnostic and Statistical Manual of Mental Disorders, 4th edn APA: Washington DC 1996

  2. Carey G, Gottesmann II . Defining cases by genetic criteria In: Wing JK, Bebbington P, Robins LW (eds) What is Case? Grant McIntyre: London 1981 pp 29–41

    Google Scholar 

  3. Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF . A family study of obsessive-compulsive disorder Am J Psychiatry 1995 152: 76–84

    Article  CAS  Google Scholar 

  4. Flament MF, Koby E, Rapoport JL . Childhood obsessive-compulsive disorder. A prospective follow-up study J Child Psycho Psychiatry 1990 31: 363–380

    Article  CAS  Google Scholar 

  5. Lesch KP . Psychobiologie der Zwangskrankheit Fortschr Neurol Psychiatr 1991 59: 404–412

    Article  CAS  Google Scholar 

  6. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S et al. Association 1996 of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 1996 274: 1527–1531

    Article  CAS  Google Scholar 

  7. Zohar J, Chopra M, Sasson Y, Aimaz R, Amital D . Obsessive compulsive disorder: serotonin and beyond. Review World J Biol Psychiatry 2000 1: 92–100

    Article  CAS  Google Scholar 

  8. Brewerton TD . Toward a unified theory of serotonin dysregulation in eating and related disorders Psychoneuroendocrinology 1995 20: 561–590

    Article  CAS  Google Scholar 

  9. Kaye WH . Anorexia nervosa, obsessional behavior, and serotonin Psychopharmacol Bull 1997 33: 335–344

    CAS  PubMed  Google Scholar 

  10. Enoch MA, Kaye WH, Rotondo A, Greenberg BD, Murphy DL, Goldman D . 5-HT2A promoter polymorphism −1438G/A, anorexia nervosa, and obsessive-compulsive disorder Lancet 1998 351: 1785–1786

    Article  CAS  Google Scholar 

  11. Jarry JL, Vaccarino FJ . Eating disorder and obsessive-compulsive disorder: neurochemical and phenomenological commonalities J Psychiatry Neurosci 1996 21: 36–47

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Hanna GL, Yuwiler A, Cantwell DP . Whole blood serotonin in juvenile obsessive-compulsive disorder Biol Psychiatry 1991 29: 738–744

    Article  CAS  Google Scholar 

  13. Zohar J, Insel TR . Obsessive-compulsive disorder. Psychobiological approaches to diagnosis, treatment, and pathophysiology Biol Psychiatry 1987 22: 667–687

    Article  CAS  Google Scholar 

  14. Pigott TA, Hill JL, Grady TA, L'Heureux F, Bernstein S, Rubenstein C-S et al. A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to i.v. mCPP Biol Psychiatry 1993 33: 3–14

    Article  CAS  Google Scholar 

  15. Arranz MJ, Munro J, Owen MJ, Purlock G, Sham PC, Zhao J et al. Evidence for association between polymorphisms in the promoter and coding regions of the 5-HT2A receptor gene and response to clozapine Mol Psychiatry 1998 3: 61–66

    Article  CAS  Google Scholar 

  16. Enoch MA, Goldman D, Barnett R, Sher L, Mazzanti CM, Rosenthal NE . Association between seasonal affective disorder and the 5-HT2A promoter polymorphism 1438G/A Mol Psychiatry 1999 4: 89–92

    Article  CAS  Google Scholar 

  17. Nakamura T, Matsushita S, Nishiguchi N, Kimura M, Yoshino A, Higuchi S . Association of a polymorphism of the 5-HT2A receptor gene promoter region with alcohol dependence Mol Psychiatry 1999 4: 85–88

    Article  CAS  Google Scholar 

  18. Collier DA, Arranz MJ, Li T, Mupita D, Brown N, Treasure J . Association between the 5-HT2A gene promotor polymorphism and anorexia nervosa Lancet 1997 350: 412

    Article  CAS  Google Scholar 

  19. Hinney A, Ziegler A, Nöthen MA, Remschmidt H, Hebebrand J . 5-HT2A receptor gene polymorphism, anorexia nervosa, and obesity Lancet 1997 350: 1324–1325

    Article  CAS  Google Scholar 

  20. Campbell DA, Sundarmurthy D, Markham AF, Pieri LF . Lack of association between 5-HT2A gene promotor polymorphism and succeptibility to anorexia nervosa Lancet 1998 351: 499

    Article  CAS  Google Scholar 

  21. Aubert R, Betoulle D, Herbeth B, Siest G, Fumeron F . 5-HT2A receptor gene polymorphism is associated with food and alcohol intake in obese people Int J Obes Relat Metab Disord 2000 24: 920–924

    Article  CAS  Google Scholar 

  22. Preuss UW, Koller G, Bondy B, Bahlmann M, Soyka M . Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: possible association but no influence of personality disorders Neuropsychobiology 2001 43: 186–191

    Article  CAS  Google Scholar 

  23. Enoch MA, Greenberg BD, Murphy DL, Goldman D . Sexually dimorphic relationship of a 5-HT2A promoter polymorphism with obsessive-compulsive disorder Biol Psychiatry 2001 49: 385–388

    Article  CAS  Google Scholar 

  24. Nicolini H, Cruz C, Camarena B, Orozco B, Kennedy JL, King N et al. DRD2, DRD3 and 5-HT2A receptor genes polymorphisms in obsessive-compulsive disorder Mol Psychiatry 1996 1: 461–465

    CAS  PubMed  Google Scholar 

  25. Frisch A, Michaelovsky E, Rockah R, Amir I, Hermesh H, Laor N et al. Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways Eur Neuropsychopharmacol 2000 10: 205–209

    Article  CAS  Google Scholar 

  26. Spurlock G, Heils A, Holmans P, Williams J, D'Soouza UM, Carno A et al. A family based association study of the T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphism in the promoter Mol Psychiatry 1998 3: 42–49

    Article  CAS  Google Scholar 

  27. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL et al. The Yale-Brown Obsessive Compulsive Scale I. Development, use, and reliability Arch Gen Psychiatry 1989 46: 1006–1011

    Article  CAS  Google Scholar 

  28. Unnewehr S, Schneider S, Margraf J (eds). Kinder-DIPS: Diagnostisches Interview bei psychischen Störungen im Kindes- und Jugendalter Springer: Berlin, Heidelberg, New York 1995

    Book  Google Scholar 

  29. Hinney A, Lentes KU, Rosenkranz K et al. Beta 3-adrenergic-receptor allele distributions in children, adolescents and young adults with obesity, underweight and anorexia nervosa Int J Obes Relat Metab Disord 1997 21: 224–230

    Article  CAS  Google Scholar 

  30. World Health Organization. Composite International Diagnostic Interview (CIDI): (a) CIDI Interview version 1.0, (b) CIDI-user manual, (c) CIDI-training manual, (d) CIDI computer programs WHO: Geneva 1990

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Acknowledgements

We thank all probands for their participation. The Bundesministerium für Bildung und Forschung (BMBF, 01KW006; 01GS0118) supported the molecular genetic and statistical analyses.

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Authors and Affiliations

  1. Department of Child and Adolescent Psychiatry, Julius-Maximilians-University, Würzburg, Germany

    S Walitza, C Wewetzer, A Warnke & M Gerlach

  2. Department of Child and Adolescent Psychiatry, Philipps-University, Marburg, Germany

    G Gerber, H Remschmidt, J Hebebrand & A Hinney

  3. Department of Child and Adolescent Psychiatry, University, Aachen, Germany

    B Herpertz-Dahlmann

  4. Department of Child and Adolescent Psychiatry, University, Freiburg, Germany

    E Schulz

  5. Institute of Medical Biometry and Epidemiology Philipps-University, Marburg, Germany

    F Geller & T Görg

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  1. S Walitza
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  10. H Remschmidt
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  11. J Hebebrand
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  12. A Hinney
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Correspondence to S Walitza.

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Walitza, S., Wewetzer, C., Warnke, A. et al. 5-HT2A promoter polymorphism −1438G/A in children and adolescents with obsessive-compulsive disorders. Mol Psychiatry 7, 1054–1057 (2002). https://doi.org/10.1038/sj.mp.4001105

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