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Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition

Molecular Psychiatry volume 8, pages 10–11 (2003)Cite this article

SIR – Heritability estimates for intelligence quotient (IQ) range from 0.50 to 0.80.1 This makes IQ a suitable target for attempts to identify the specific genes involved. This first such gene to be identified was by Chorney et al.2 They reported an association between the insulin-like growth factor 2 receptor (IGF2R) gene and IQ. Cholinergic pathways have been widely implicated in cognition and memory,3,4 making the respective genes excellent candidate markers for cognitive abilities. Identification of a possible role of cholinergic receptor genes in humans has been hampered by the lack of reported polymorphisms. We identified a common A→T 1890 polymorphism in the 3′UTR of the CHRM2 gene. To determine if it was associated with IQ, we examined 358 adult males and 470 adult females for a total of 828 adults.

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Authors and Affiliations

  1. Department of Medical Genetics, City of Hope Medical Center, Duarte, 91010, CA, USA

    D E Comings, S Wu & M Rostamkhani

  2. Department of Psychology, University of Minnesóta, Minneapolis, MN, USA

    M McGue & W G lacono

  3. Department of Genomics, MGI Applied Genomics, Long Beach, CA, USA

    J P MacMurray

  4. Department of Biostatistics, City of Hope Medical Center, Duarte, 91010, CA, USA

    L S-C Cheng

Authors
  1. D E Comings
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  2. S Wu
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  3. M Rostamkhani
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  4. M McGue
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  5. W G lacono
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  6. L S-C Cheng
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  7. J P MacMurray
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Comings, D., Wu, S., Rostamkhani, M. et al. Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition. Mol Psychiatry 8, 10–11 (2003). https://doi.org/10.1038/sj.mp.4001095

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