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The missense mutation in the WKL1 gene not found in patients with bipolar affective disorder

Molecular Psychiatry volume 7, pages 340–341 (2002)Cite this article

SIR – We have, with great interest, read the recent study which found a C to A missense mutation in the neurogene WKL1 in patients with catatonic schizophrenia from a single German pedigree.1 Meyer et al1 suggested that this gene should be investigated among patients with other psychiatric disorders. We searched for the WKL1 mutation among 80 patients with bipolar affective disorder and 84 controls from Denmark.

Patients and controls were unrelated Danish Caucasians. All cases met the ICD-10 diagnostic criteria for bipolar affective disorder and 79 fulfilled DSM-III-R criteria for bipolar disorder, the remaining patient was classified as having mania with psychosis. Only patients with an age of onset before 35 years were included. The patients were all interviewed using the semi-structured interview SCAN.2 Consensus best-estimate of lifetime diagnosis was made independently by two senior psychiatrists. Further details of the sample have been reported previously.3,4 To detect the polymorphism we used a primer extension assay and analyzed reaction products on an ABI 310 automated sequencer (Applied Biosystems, Foster City, CA, USA). Primers used for the polymerase chain reaction were WKL1F (5′-GGGCCACTCTGCTCACACCT-3′) and WKL1R (5′-TTCTGGGTGTCCCAGGATGC-3′) and in the extension reaction WKL1S (5′CGGCCTGCA GCAGGAGCACTAGCA-3′).

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Authors and Affiliations

  1. Department of Biological Psychiatry, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, Risskov, DK-8240, Denmark

    H Ewald & M D Lundorf

  2. Department of Psychiatric Demography, Psychiatric Hospital in Aarhus, Risskov, DK-8240, Denmark

    H Ewald

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  1. H Ewald
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  2. M D Lundorf
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Correspondence to H Ewald.

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Ewald, H., Lundorf, M. The missense mutation in the WKL1 gene not found in patients with bipolar affective disorder. Mol Psychiatry 7, 340–341 (2002). https://doi.org/10.1038/sj.mp.4001002

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