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News about disturbances of neuronal migration bring views to bipolar disorder

Molecular Psychiatry volume 5, pages 462–464 (2000)Cite this article

Recently, Fox et al from the Harvard Institute of Medicine, identified the bilateral periventricular nodular heterotopia (BPNH) gene correspondent to filamin 1 (FLN1), which encodes an actin-crosslinking phosphoprotein that transduces ligand-receptor binding into actin reorganization, and which is required for locomotion of many cell types. High-level expression of FLN1 in the developing cortex is required for neuronal migration to the cortex, and is essential for embryogenesis.1

Currently there exist data on the molecular mechanisms involving Filamin 1. Ohta et al have studied the action of the small GTPase RA1A inducing filopodia using filamin in this pathway.2

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  1. Department of Biology, Institute of Biosciences, University of São Paulo, Brazil, Laboratory of Imunopathology Keizo Asami, Federal University of Pernambuco, CEP 50730–670, Recife-Pernambuco, Brazil

    J R M Oliveira

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Oliveira, J. News about disturbances of neuronal migration bring views to bipolar disorder. Mol Psychiatry 5, 462–464 (2000). https://doi.org/10.1038/sj.mp.4000764

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