Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Research Article
  • Published:

Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5

Molecular Psychiatry volume 4, pages 558–565 (1999)Cite this article

Abstract

The dopaminergic system has been implicated in the aetiology of mood disorders. We conducted family-based association studies for polymorphisms at three genes involved in the metabolism of dopamine: dopamine transporter (DAT1), dopamine-β-hydroxylase (DBH) and catechol-O-methyl transferase (COMT); and three dopamine receptors: DRD2, DRD3 and DRD5. We used a sample of 122 parent–offspring trios of British Caucasian origin where the proband had bipolar disorder I (BPI), and analysed the results with the transmission/disequilibrium test (TDT) which is robust to hidden population stratification. No statistically significant differences were found between transmitted and not transmitted alleles for any of the polymorphisms studied.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Divisions of Psychological Medicine and Medical Genetics, Neuropsychiatric Genetics Unit, Tenovus Building, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN, UK

    G Kirov & M J Owen

  2. Department of Psychiatry, University of Birmingham, Queen Elizabeth Psychiatric Hospital, Birmingham, B15 2QZ, UK

    I Jones, F McCandless & N Craddock

Authors
  1. G Kirov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F McCandless
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N Craddock
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M J Owen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G Kirov.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kirov, G., Jones, I., McCandless, F. et al. Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5. Mol Psychiatry 4, 558–565 (1999). https://doi.org/10.1038/sj.mp.4000565

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.mp.4000565

Keywords

This article is cited by

Search

Advanced search

Quick links