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Puzzles of psychiatric genetics—new candidate gene approaches


Bipolar disorder and schizophrenia may show ‘anticipation,’ or earlier age-of-onset in successive generations within a pedigree, suggesting that triplet repeat expansion mutations could play a causative role in these disorders. This genetic hypothesis can be tested using a candidate gene approach.

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Ross, C., Margolis, R. Puzzles of psychiatric genetics—new candidate gene approaches. Mol Psychiatry 2, 432–433 (1997).

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