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5-HT1D and 5-HT1E/1F binding sites in depressed suicides: increased 5-HT1D binding in globus pallidus but not cortex

Abstract

5-HT1D and 5-HT1E/1F receptor binding sites were measured in brain samples obtained at post-mortem from suicide victims with a firm retrospective diagnosis of depression, and matched controls. In antidepressant-free suicides a significantly higher number of 5-HT1D receptors was found in globus pallidus. This was largely restricted to those suicides who died by violent means. This effect was not observed in antidepressant-treated suicides. No differences or trends in 5-HT1D binding were found in putamen, parietal or frontal cortex, in antidepressant-free or antidepressant-treated suicides. There were no differences in the number of 5-HT1E/1F receptors in any of the regions studied.

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Lowther, S., Katona, C., Crompton, M. et al. 5-HT1D and 5-HT1E/1F binding sites in depressed suicides: increased 5-HT1D binding in globus pallidus but not cortex. Mol Psychiatry 2, 314–321 (1997). https://doi.org/10.1038/sj.mp.4000259

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  • DOI: https://doi.org/10.1038/sj.mp.4000259

Keywords

  • 5-HT1D receptor binding sites
  • 5-HT1E/1F receptor binding sites
  • suicide
  • depression
  • post-mortem brain tissue
  • antidepressant drugs
  • cerebral cortex
  • putamen
  • globus pallidus
  • basal ganglia

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