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Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue

Abstract

A profound inflammatory response is initiated immediately following traumatic brain injury (TBI) and is characterized by the release of several cytokines with pro- and anti-inflammatory functions. In order to elucidate which cytokines are released in the human brain in response to injury as well as in the peripheral compartment, IL-1, IL-6, IL-8, IL-10, TNF-α and TGF-β were monitored in CSF and serum of severely brain-injured patients. Furthermore, we investigated the possible modulation of systemic reactions by IL-6 and the ability of IL-6 and IL-8 to promote the synthesis of nerve growth factor.

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Morganti-Kossman, M., Lenzlinger, P., Hans, V. et al. Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue. Mol Psychiatry 2, 133–136 (1997). https://doi.org/10.1038/sj.mp.4000227

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  • DOI: https://doi.org/10.1038/sj.mp.4000227

Keywords

  • brain injury
  • interleukins
  • tumor necrosis factor-alpha
  • transforming growth factor-beta
  • nerve growth factor
  • astrocytes
  • acute-phase-response
  • blood–brain barrier

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