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Physical activity and erectile dysfunction: meta-analysis of population-based studies

International Journal of Impotence Research volume 19, pages 245–252 (2007)Cite this article

Abstract

We searched for population-based cross-sectional studies, cohort studies and randomized controlled trials (RCTs) on erectile dysfunction (ED) through Medline, PubMed, PsychInfo and scanned though reference lists. Studies that did not include adjusted odds ratios (OR) of physical activity were excluded. Seven cross-sectional studies were suitable for meta-analysis, and the results from one cross-section study, two cohort studies and one RCT were summarized. Pooling the ORs using random effects models, we derived summary estimate for adjusted OR of physical activity in those with ED compared with those without ED, which was 0.53 (0.31, 0.91). Moderate and high physical activities were associated with a lower risk of ED, with ORs at 0.63 (0.43, 0.93) and 0.42 (0.22, 0.82), respectively. Funnel plot by visual inspection, and Begg's test and Egger's test did not detect significant publication bias. Sensitivity analyses revealed that the summary estimate from the random effects model was robust to changes in study sample size and level of statistical adjustment, but not so robust to changes in ED definition, although the summary estimate for each ED definition did not differ significantly. Although causality cannot be demonstrated from cross-sectional studies, the apparent ‘protective’ effect of physical activity on ED should be further investigated using large-scale cohort studies or RCTs.

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Abbreviations

ED:

erectile dysfunction

IIEF:

International Index of Erectile Function

HPFS:

Health Professionals Follow-up Study

MMAS:

Massachusetts Male Aging Study

CI:

confidence interval

RCT:

randomized controlled trials

References

  1. Thompson IM, Tangen CM, Goodman PJ, Probstfield JL, Moinpour CM, Coltman CA . Erectile dysfunction and subsequent cardiovascular disease. JAMA 2005; 294 (23): 2996–3002.

    Article  CAS  PubMed  Google Scholar 

  2. Thomas GN, Tomlinson B, Abdullah AS, Yeung VT, Chan JC, Wong KS . Association of erectile dysfunction with cardiovascular risk factors and increasing existing vascular disease in male Chinese type 2 diabetic patients. Diabetes Care 2005; 28 (8): 2051–2053.

    Article  PubMed  Google Scholar 

  3. Le NA . Inflammation, oxidative stress, and atherosclerosis. Curr Opin Lipidol 2004; 15 (2): 227–229.

    Article  CAS  PubMed  Google Scholar 

  4. Prins J, Blanker MH, Bohnen AM, Thomas S, Bosch JL . Prevalence of erectile dysfunction: a systematic review of population-based studies. Int J Impot Res 2002; 14 (6): 422–432.

    Article  CAS  PubMed  Google Scholar 

  5. Shaeer KZ, Osegbe DN, Siddiqui SH, Razzaque A, Glasser DB, Jaguste V . Prevalence of erectile dysfunction and its correlates among men attending primary care clinics in three countries: Pakistan, Egypt, and Nigeria. Int J Impot Res 2003; 15 (Suppl 1): S8–S14.

    Article  PubMed  Google Scholar 

  6. Moreira Jr ED, Lisboa Lobo CF, Villa M, Nicolosi A, Glasser DB . Prevalence and correlates of erectile dysfunction in Salvador, northeastern Brazil: a population-based study. Int J Impot Res 2002; 14 (Suppl 2): S3–S9.

    Article  PubMed  Google Scholar 

  7. Akkus E, Kadioglu A, Esen A, Doran S, Ergen A, Anafarta K et al. Prevalence and correlates of erectile dysfunction in Turkey: a population-based study. Eur Urol 2002; 41 (3): 298–304.

    Article  PubMed  Google Scholar 

  8. Bai Q, Xu QQ, Jiang H, Zhang WL, Wang XH, Zhu JC . Prevalence and risk factors of erectile dysfunction in three cities of China: a community-based study. Asian J Androl 2004; 6 (4): 343–348.

    PubMed  Google Scholar 

  9. Nicolosi A, Moreira Jr ED, Shirai M, Bin Mohd Tambi MI, Glasser DB . Epidemiology of erectile dysfunction in four countries: cross-national study of the prevalence and correlates of erectile dysfunction. Urology 2003; 61 (1): 201–206.

    Article  PubMed  Google Scholar 

  10. Millett C, Wen LM, Rissel C, Smith A, Richters J, Grulich A et al. Smoking and erectile dysfunction: findings from a representative sample of Australian men. Tob Control 2006; 15 (2): 136–139.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Parazzini F, Menchini Fabris F, Bortolotti A, Calabro A, Chatenoud L, Colli E et al. Frequency and determinants of erectile dysfunction in Italy. Eur Urol 2000; 37 (1): 43–49.

    Article  CAS  PubMed  Google Scholar 

  12. Mak R, De Backer G, Kornitzer M, De Meyer JM . Prevalence and correlates of erectile dysfunction in a population-based study in Belgium. Eur Urol 2002; 41 (2): 132–138.

    Article  PubMed  Google Scholar 

  13. Fedele D, Bortolotti A, Coscelli C, Santeusanio F, Chatenoud L, Colli E et al. Erectile dysfunction in type 1 and type 2 diabetics in Italy. On behalf of Gruppo Italiano Studio Deficit Erettile nei Diabetici. Int J Epidemiol 2000; 29 (3): 524–531.

    Article  CAS  PubMed  Google Scholar 

  14. Cho BL, Kim YS, Choi YS, Hong MH, Seo HG, Lee SY et al. Prevalence and risk factors for erectile dysfunction in primary care: results of a Korean study. Int J Impot Res 2003; 15 (5): 323–328.

    Article  CAS  PubMed  Google Scholar 

  15. Terai A, Ichioka K, Matsui Y, Yoshimura K . Association of lower urinary tract symptoms with erectile dysfunction in Japanese men. Urology 2004; 64 (1): 132–136.

    Article  PubMed  Google Scholar 

  16. Tan JK, Hong CY, Png DJ, Liew LC, Wong ML . Erectile dysfunction in Singapore: prevalence and its associated factors—a population-based study. Singapore Med J 2003; 44 (1): 20–26.

    CAS  PubMed  Google Scholar 

  17. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB . Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med 2003; 139 (3): 161–168.

    Article  PubMed  Google Scholar 

  18. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB . A prospective study of risk factors for erectile dysfunction. J Urol 2006; 176 (1): 217–221.

    Article  PubMed  Google Scholar 

  19. Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB et al. Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med 2000; 30 (4): 328–338.

    Article  CAS  PubMed  Google Scholar 

  20. Esposito K, Giugliano F, Di Palo C, Giugliano G, Marfella R, D'Andrea F et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. JAMA 2004; 291 (24): 2978–2984.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Psychiatry, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong

    J Y W Cheng, E M L Ng, J S N Ko & R Y L Chen

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  1. J Y W Cheng
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  2. E M L Ng
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Correspondence to J Y W Cheng.

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Cheng, J., Ng, E., Ko, J. et al. Physical activity and erectile dysfunction: meta-analysis of population-based studies. Int J Impot Res 19, 245–252 (2007). https://doi.org/10.1038/sj.ijir.3901521

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  • DOI: https://doi.org/10.1038/sj.ijir.3901521

Keywords

  • physical activity
  • erectile dysfunction
  • epidemiology
  • exercise
  • sexual dysfunction
  • meta-analysis

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