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Semiquantitative imaging measurement of baseline and vasomodulated normal prostatic blood flow using sildenafil


The physiologic variability of blood flow to the prostate has not been studied until this time. We report the vasoactive effects of sildenafil and phenylephrine on blood flow of the normal prostate. Sildenafil increases prostate blood flow by approximately 75% and phenylephrine reduces the flow incrementally. Administration of these drugs with dynamic contrast-enhanced magnetic resonance imaging may improve the diagnosis of cancerous tissue because according to the literature, tumor angiogenic vessels lack the vasoactive physiologic response of the normal tissue.

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  1. Buckley DL, Roberts C, Parker GJ, Logue JP, Hutchinson CE . Prostate cancer: evaluation of vascular characteristics with dynamic contrast-enhanced T1-weighted MR imaging – initial experience. Radiology 2004; 233: 709–715.

    Article  Google Scholar 

  2. Sommer FG, Nghiem HV, Herfkens R, McNeal J . Gadolinium-enhanced MRI of the abnormal prostate. Magn Reson Imaging 1993; 11: 941–948.

    Article  CAS  Google Scholar 

  3. Preziosi P, Orlacchio A, Di Giambattista G, Di Renzi P, Bortolotti L, Fabiano A, Cruciani E, Pasqualetti P . Enhancement patterns of prostate cancer in dynamic MRI. Eur Radiol 2003; 13: 925–930.

    PubMed  Google Scholar 

  4. Noworolski SM, Henry RG, Vigneron DB, Kurhanewicz J . Dynamic contrast-enhanced MRI in normal and abnormal prostate tissues as defined by biopsy, MRI, and 3D MRSI. Magn Reson Med 2005; 53: 249–255.

    Article  CAS  Google Scholar 

  5. Padhani AR, Gapinski CJ, MacVicar DA, Parker GJ, Suckling J, Revell PB et al. Dynamic contrast enhanced MRI of prostate cancer: correlation with morphology and tumour stage, histological grade and PSA. Clin Radiol 2000; 55: 99–109.

    Article  CAS  Google Scholar 

  6. Oyen RH . Dynamic contrast-enhanced MRI of the prostate: is this the way to proceed for characterization of prostatic carcinoma? Eur Radiol 2003; 13: 921–924.

    CAS  PubMed  Google Scholar 

  7. Mattsson J, Lilja J, Peterson HI . Influence of vasoactive drugs on local tumor blood flow. Eur J Cancer Clin Oncol 1982; 18: 677–684.

    Article  CAS  Google Scholar 

  8. Mattson J, Appelgren L, Karlsson L, Peterson HI . Influence of vasoactive drugs and ischaemia on intra-tumour blood flow distribution. Eur J Cancer 1978; 14: 761–764.

    Article  CAS  Google Scholar 

  9. Hori K, Zhang QH, Saito S, Tanda S, Li HC, Suzuki M . Microvasculare mechanisms of change in tumor blood flow due to aniotensin II, epinephrine and methoxamine: a functional morphometric study. Cancer Res 1993; 53: 5528–5534.

    CAS  Google Scholar 

  10. Zlotecki RA, Baxter LT, Boucher Y, Jain RK . Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: network analysis and mechanistic interpretation. Microvasc Res 1995; 50: 429–443.

    Article  CAS  Google Scholar 

  11. Medina P, Segarra G, Vila J, Domenech C, Martinez-Leon JB, Lluch S et al. Effects of sildenafil on human penile blood vessels. Urology 2000; 56: 539–543.

    Article  CAS  Google Scholar 

  12. Lowe FC, Jarow JP . Placebo-controlled study of oral terbutaline and pseudoephedrine in management of prostaglandin E1-induced prolonged erections. Urology 1993; 42: 51–53.

    Article  CAS  Google Scholar 

  13. Uckert S, Oelke M, Stief CG, Andersson KE, Jonas U, Hedlund P . Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE)isoenzymes in the human prostate. Eur Urol 2006; Jan 18 [E-pub ahead of print].

  14. Preston A, Frydenberg M, Haynes JM . A1 and A2A adenosine receptor modulation of alpha 1-adrenoceptor-mediated contractility in human cultured prostatic stromal cells. Br J Pharmacol 2004; 141: 302–310.

    Article  CAS  Google Scholar 

  15. Sadeghi-Nejad H, Dogra V, Seftel AD, Mohamed MA . Priapism. Radiol Clin North Am 2004; 42: 427–443.

    Article  Google Scholar 

  16. Eberhard A, Kahlert S, Goede V, Bernhard H, Hemmerlein B, Plate KH et al. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res 2000; 60: 1388–1393.

    CAS  PubMed  Google Scholar 

  17. Haaga J . Interventional CT: 30 years experience. Eur Radiol 2005; 15: D116–D120.

    Article  Google Scholar 

  18. Qian C, Takahashi M, Kahnoski RJ, Teh BT . Effect of sildenafil citrate on an orthotopic prostate cancer growth and metastasis model. J Urol 2003; 170: 994–997.

    Article  CAS  Google Scholar 

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We thank Jack Jesberger for reviewing the technical aspects of the MRI data.

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Correspondence to J R Haaga.

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Haaga, J., Exner, A., Fei, B. et al. Semiquantitative imaging measurement of baseline and vasomodulated normal prostatic blood flow using sildenafil. Int J Impot Res 19, 110–113 (2007).

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