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Efficacy of sertraline hydrochloride in treatment of premature ejaculation: a placebo-controlled study using a validated questionnaire

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are increasingly used to treat premature ejaculation. We report a large prospective placebo-controlled crossover study of sertraline in premature ejaculation (PE) using Arabic Index of Premature Ejaculation (AIPE). One hundred and forty-seven men suffering from PE were enrolled in a randomized single-blinded crossover study of sertraline hydrochloride and placebo. Patients were randomized into group 1 (n=77) and group 2 (n=70). Both groups received sertraline and placebo interchangeably for 4 weeks. Overall, 127 (81%) of 157 subjects experienced a significant increase in their AIPE total score after sertraline treatment. Sixty-six (66%) of 100 patients available for follow-up experienced relapse of PE within 6 months after sertraline withdrawal. The active drug was generally well tolerated. Our relatively large study, using a validated questionnaire (AIPE), confirmed the useful effect of sertraline on PE.

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References

  1. Frank E, Anderson C, Rubinstein D . Frequency of sexual dysfunction in ‘normal’ couples. N Engl J Med 1978; 299: 111–115.

    Article  CAS  Google Scholar 

  2. Schein M, Zyzanski SJ, Levine S, Medalie JH, Dickman RL, Alemagno SA . The frequency of sexual problems among family practice patients. Fam Prac Res J 1988; 7: 122–134.

    CAS  Google Scholar 

  3. Montoris F . Prevalence of premature ejaculation: a global and regional perspective. J Sex Med 2005; 2: 96–102.

    Article  Google Scholar 

  4. McMahon CG . Treatment of premature ejaculation with sertralineHCl: a single-blind placebo controlled crossover study. J Urol 1998; 159: 1935–1938.

    Article  CAS  Google Scholar 

  5. American Psychiatry Association. Diagnostic and Statistical Manual of Mental Disorders, DSM-IV, 4th edn, American Psychiatric Association: Washington, DC, 1994; 509–511.

  6. Masters WH, Johnson VE . Human sexual inadequacy. Little, Brown & Co.: Boston, MA, 1970; 92–115.

    Google Scholar 

  7. Lue TF, Giuliano F, Montorsi F, Rosen RC, Andersson KE, Althof S et al. Summary of the recommendation on sexual dysfunctions in men. J Sex Med 2004; 1: 6–23.

    Article  Google Scholar 

  8. Waldinger MD, Quinn P, Dilleen M, Mundayat R, Schweitzer DH, Boolell M . A multi-national population survey of intravaginal ejaculation latency time. J Sex Med 2005; 2: 492–497.

    Article  Google Scholar 

  9. Waldinger MD, Zwinderman AH, Olivier B, Schweitzer DH . Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data. J Sex Med 2005; 2: 498–507.

    Article  Google Scholar 

  10. Arafa M, Shamloul R . Development and evaluation of the Arabic Index of Premature Ejaculation (AIPE). J Sex Med 2005 (in press).

  11. McMahon CG . Treatment of premature ejaculation with sertraline hydrochloride. Int J Impot Res 1998; 10: 181–184.

    Article  CAS  Google Scholar 

  12. Waldinger MD, Zwinderman AH, Schweitzer DH, Olivier B . Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res 2004; 16: 369–381.

    Article  CAS  Google Scholar 

  13. Shamloul R, Ghanem H, Abou-zeid A . Validity of the Arabic version of the sexual health inventory for men among Egyptians. Int J Impot Res 2004; 16: 452–455.

    Article  CAS  Google Scholar 

  14. Waldinger MD . Lifelong premature ejaculation: definition, serotonergic neurotransmission and drug treatment. World J Urol 2005; 23: 102–108.

    Article  CAS  Google Scholar 

  15. Olivier B, van Oorschot R, Waldinger MD . Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour. Int Clin Psychopharmacol 1998; 13 (Suppl 6): S9–S14.

    Article  Google Scholar 

  16. Waldinger MD, Berendsen HH, Blok BF, Olivier B, Holstege G . Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system. Behav Brain Res 1998; 92: 111–118.

    Article  CAS  Google Scholar 

  17. Mendels J, Camera A, Sikes C . Sertraline treatment for premature ejaculation. J Clin Psychopharmacol 1995; 15: 341–346.

    Article  CAS  Google Scholar 

  18. Kara H, Aydin S, Yucel M, Agargun MY, Odabas O, Yilmaz Y . The efficacy of fluoxetine in the treatment of premature ejaculation: a double-blind, placebo controlled study. J Urol 1996; 156: 1631–1632.

    Article  CAS  Google Scholar 

  19. Waldinger MD, Hengeveld MW, Zwinderman AH . Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry 1994; 151: 1377–1379. 7.

    Article  CAS  Google Scholar 

  20. Waldinger MD, Hengeveld MW, Zwinderman AH . Ejaculation retarding properties of paroxetine in patients with primary premature ejaculation: a double-blind, randomized, dose–response study. Br J Urol 1997; 79: 592–595.

    Article  CAS  Google Scholar 

  21. McMahon CG . Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study. J Urol 1998; 159: 1935–1938.

    Article  CAS  Google Scholar 

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Correspondence to R Shamloul.

Appendix A1

Appendix A1

Arabic Index of Premature Ejaculation

Patient's name:______________ Patient's number:____________

Please respond to each question by circling ONLY ONE statement that best describes your condition.

Q1. How do you rate your sexual desire?

  1. a)

    very low

  2. b)

    low

  3. c)

    average

  4. d)

    high

  5. e)

    very high

Q2. How often do you have hard erections, with sexual stimulation, sufficient to complete sexual intercourse?

  1. a)

    almost never

  2. b)

    rarely

  3. c)

    sometimes

  4. d)

    often

  5. e)

    most of the time

Q3. How much time does it take from intromission to ejaculation (using a stop-watch)?

  1. a)

    <30 s

  2. b)

    around 1 min

  3. c)

    1–2 min

  4. d)

    2–3 min

  5. e)

    >3 min

Q4. How difficult is it for you to prolong your ejaculation time?

  1. a)

    most of the time

  2. b)

    often

  3. c)

    sometimes

  4. d)

    rarely

  5. e)

    almost never

Q5. How often was sexual intercourse satisfactory for you?

  1. a)

    almost never

  2. b)

    rarely

  3. c)

    sometimes

  4. d)

    often

  5. e)

    most of the time

Q6. How often was sexual intercourse satisfactory for your partner?

  1. a)

    almost never

  2. b)

    rarely

  3. c)

    sometimes

  4. d)

    often

  5. e)

    most of the time

Q7. During sexual intercourse, do you feel anxious, depressed or stressed?

  1. a)

    most of the time

  2. b)

    often

  3. c)

    sometimes

  4. d)

    rarely

  5. e)

    almost never

Date of assessment:_________________Doctor's initials:__________

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Arafa, M., Shamloul, R. Efficacy of sertraline hydrochloride in treatment of premature ejaculation: a placebo-controlled study using a validated questionnaire. Int J Impot Res 18, 534–538 (2006). https://doi.org/10.1038/sj.ijir.3901469

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  • DOI: https://doi.org/10.1038/sj.ijir.3901469

Keywords

  • premature ejaculation
  • sertraline
  • questionnaires

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