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Hormone levels in middle-aged and elderly men with and without erectile dysfunction in Taiwan

Abstract

The change in sexual hormones with age in middle-aged and elderly Chinese men, with and without erectile dysfunction (ED), was investigated. Total testosterone (TT), free testosterone (FT), dehydroepiandrosterone sulfate (DHEAS), and sex hormone-binding globulin (SHBG) were determined from fasting serum samples by radioimmunoassay in 627 middle-aged and elderly ethnic Chinese men with and without ED. Calculated FT was derived from TT and SHBG. Patients with ED were subdivided into groups having low serum TT (<2.7 ng/ml) and normal TT (2.7 ng/ml). FT and DHEAS declined and SHBG rose with age in both normal patients and in patients with ED. TT and SHBG were lower in patients with ED than in normal subjects at all ages. In contrast to findings in previous studies, levels of FT were higher in patients with ED than in normal subjects. Hormonal changes in this Chinese population generally mirrored those in previously studied ethnic populations, except for higher FT in patients with ED. This suggests that hormonal levels in patients with ED may vary in different populations. The significance and reproducibility of this finding remains to be determined.

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References

  1. Gooren LJG . The age-related decline of androgen levels in men: clinically significant? Br J Urol 1996; 78: 763–768.

    Article  CAS  PubMed  Google Scholar 

  2. Becker AJ, Uckert S, Stief CG, Truss MC, Hartmann U, Jonas U et al. Cavernous and systemic testosterone levels in different phases of human penile erection. Urology 2000; 56: 125–129.

    Article  CAS  PubMed  Google Scholar 

  3. Kaufman JM, T’Sjoen G . The effects of testosterone deficiency on male sexual function. Aging Male 2002; 5: 242–247.

    Article  CAS  PubMed  Google Scholar 

  4. Fahmy AK, Mitra S, Blacklock ARE, Desai KM . Is the measurement of serum testosterone routinely indicated in men with erectile dysfunction? Br J Urol Int 1999; 84: 482–484.

    Article  CAS  Google Scholar 

  5. Aversa A, Isidori AM, Martino MUD, Caprio M, Fabbrini E, Rocchietti-March M et al. Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilation in men with erectile dysfunction. Clin Endocrinol 2000; 53: 517–522.

    Article  CAS  Google Scholar 

  6. Alcorn JF, Toepfer JR, Leipheimer RE . The effect of castration on relaxation of rat corpus cavernosum smooth muscle in vitro. J Urol 1999; 161: 686–689.

    Article  CAS  PubMed  Google Scholar 

  7. Greenstein A, Plymate SR, Kartz PG . Visually stimulated erection in castrated men. J Urol 1995; 153: 650–652.

    Article  CAS  PubMed  Google Scholar 

  8. Rhoden EL, Telöken C, Sogari PR, Souto CAV . The relationship of serum testosterone on erectile function in normal aging men. J Urol 2002; 167: 1745–1748.

    Article  CAS  PubMed  Google Scholar 

  9. Foresta C, Caretta N, Rossato A, Garolla A, Ferlin A . Role of androgens in erectile function. J Urol 2004; 171 (6): 2358–2362.

    Article  CAS  PubMed  Google Scholar 

  10. Longcope C, Goldfield SRW, Brambilla DJ, McKinlay J . Androgens, estrogens and sex hormone-binding globulin in middle-aged men. J Clin Endocrinol Metab 1990; 71: 142–145.

    Google Scholar 

  11. Tenover, JS . Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 1992; 75: 1092–1098.

    CAS  PubMed  Google Scholar 

  12. Rosen RC, Cappalleri JC, Smith MD, Lipsky J, Pena MB . Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as diagnostic tool for erectile dysfunction. Int J Impot Res 1999; 11 (6): 319–326.

    Article  CAS  PubMed  Google Scholar 

  13. Vermeulen A, Verdonck L, Kaufman JM . A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84: 3666–3672.

    Article  CAS  PubMed  Google Scholar 

  14. Vermeulen A, Verdonck G . Representativeness of a single point plasma testosterone level for the long-term hormonal milieu in men. J Clin Endocrinol Metab 1992; 74: 939–942.

    Article  CAS  PubMed  Google Scholar 

  15. Zitzmann M, Nieschlay E . Testosterone levels in healthy men and the relation to behavioral and physical characteristics, facts and constructs. Eur J Endocrinol 2001; 144: 183–197.

    Article  CAS  PubMed  Google Scholar 

  16. Purifoy FE, Koopmans LH, Mayes DM . Age differences in serum, androgen levels in normal adults males. Hum Biol 1981; 53: 499–511.

    CAS  PubMed  Google Scholar 

  17. Vermeulen A, Kaufman JM . Ageing of the hypothalamo–pituitary–testicular axis in men. Horm Res 1995; 43 (1–3): 25–28.

    Article  CAS  PubMed  Google Scholar 

  18. Christ-Crain M, Mueller B, Gasser TC, Kraenzlin M, Trummler M, Huber P et al. Is there a clinical relevance of partial androgen deficiency of the aging male? J Urol 2004; 172: 624–627.

    Article  CAS  PubMed  Google Scholar 

  19. Heald AH, Ivison F, Anderson SG, Cruickshank K, Laing I, Gibson JM . Significant ethnic variation in total and free testosterone concentration. Clin Endocrinol 2003; 58 (3): 262–266.

    Article  CAS  Google Scholar 

  20. Tsujimura A, Matsumiya K, Matsuoka Y, Takahashi T, Koga M, Iwasa A et al. Bioavailable testosterone with age and erectile dysfunction. J Urol 2003; 170 (6 Part 1): 2345–2347.

    Article  CAS  PubMed  Google Scholar 

  21. Ahn HS, Park CM, Lee SW . The clinical relevance of sex hormone levels and sexual activity in the ageing male. BJU Int 2002; 89 (6): 526–530.

    Article  CAS  PubMed  Google Scholar 

  22. Veldhuis JD, Bae A, Swerdloff RS, Iranmanesh A, Wang C . Experimentally induced androgen depletion accentuates ethnicity-related contrasts in luteinizing hormone secretion in Asian and Caucasian men. J Clin Endocrinol Metab 2004; 1-.1210/jc.2004-1362.

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Correspondence to T I-S Hwang.

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Hwang, TS., Juang, GD., Yeh, CH. et al. Hormone levels in middle-aged and elderly men with and without erectile dysfunction in Taiwan. Int J Impot Res 18, 160–163 (2006). https://doi.org/10.1038/sj.ijir.3901382

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