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The relationship between lipid profile and erectile dysfunction

A Retraction to this article was published on 03 November 2007


The objective of this study is to investigate the relation between serum lipids (cholesterol, LDL, HDL, triglyceride (TG)) and erectile dysfunction (ED). The experimental methods involved comparison of 100 patients with organic ED (mean age of 43.59±10.51 y), with 100 healthy individuals (mean age of 43.72±9.76 y) regarding their lipid profile from January 2000 to June 2003 (cholesterol, TG, HDL, LDL). The results showed that there was a significant difference between mean plasma cholesterol and LDL levels in the individuals suffering from ED and the control group (P=0.04 and 0.02, respectively). The TG and HDL mean plasma level differences were not significant (P=0.583 and 0.299, respectively). Odds ratios for high plasma cholesterol level (>240 mg/dl) and high plasma LDL level (>160 mg/dl) were 1.74 and 1.97. The R2 was 0.04 for both cholesterol and LDL. Applying linear regression, the coefficient for cholesterol and LDL reduced the International Index of Erectile Function questionnaire scores by −0.036 and −0.035. In conclusion, this study, the correlation of cholesterol and LDL levels with ED strongly supports the role of hyperlipidemia treatment in both the prevention and management of ED.

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  1. Lewis R, Hatzichristou D, Laumann E, McKinlay J . Epidemiology and natural history of erectile dysfunction; risk factors including iatrogenic and aging. In: Jardin A, Wagner G, Khoury S, Giuliano F, Padma-Nathan H, Rosen R (eds). Erectile Dysfunction. First International Consultation on Erectile Dysfunction. Health Publications, Ltd.: Plymouth, 2000, pp 21–52.

    Google Scholar 

  2. Broderick GA . Intracavernous pharmacotherapy. Treatment for the aging erectile response. Urol Clin N Am 1995; 23: 111–126.

    Article  Google Scholar 

  3. Johannes CB et al. Incidence of erectile dysfunction in men 40 to 69 years old: longitudinal results from the Massachusetts Male Aging Study. J Urol 2000; 163: 460–463.

    Article  CAS  Google Scholar 

  4. Mellinger BC, Weiss J . Sexual dysfunction in the elderly male. Am Urol Assoc Update Ser 1992; 11: 146–152.

    Google Scholar 

  5. Virag R, Boully P, Frydman D . Is impotence an arterial disorder? Lancet 1985; 1: 181–184.

    Article  CAS  Google Scholar 

  6. Juenemann KP et al. Does lipid metabolism influence the pathogenesis of vascular impotence? Int J Impot Res 1990; 2(Suppl 2): 33.

    Google Scholar 

  7. Sullivan ME, Keoghane SR, Miller MAW . Vascular risk factors and erectile dysfunction. BJU Int 2001; 87: 838–845.

    Article  CAS  Google Scholar 

  8. Tanner FC et al. Oxidised low density lipoproteins inhibit relaxations of porcine coronary arteries. Circulation 1991; 83: 2012–2020.

    Article  CAS  Google Scholar 

  9. Rosenfeld ME . Oxidised LDL affects multiple atherogenic cellular responses. Circulation 1991; 83: 2137–2140.

    Article  CAS  Google Scholar 

  10. Kugiyama K et al. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature 1990; 344: 160–162.

    Article  CAS  Google Scholar 

  11. Leung WH, Lau CP, Wong CK . Beneficial effect of cholesterol-lowering therapy on coronary endothelium-dependent relaxation in hypercholesterolaemic patients. Lancet 1993; 341: 1496–1500.

    Article  CAS  Google Scholar 

  12. Saltzman EA, Guay AT, Jacobson J . Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: a clinical observation. J Urol 2004; 172: 255–258.

    Article  Google Scholar 

  13. Azadzoi KM, Saenz de Tejada I . Hypercholesterolaemia impairs endothelium dependent relaxation of rabbit corpus cavernosum smooth muscle. J Urol 1991; 146: 238–240.

    Article  CAS  Google Scholar 

  14. Kim JH et al. Experimental hypercholesterolaemia in rabbits induces cavernosal atherosclerosis with endothelial and smooth muscle cell dysfunction. J Urol 1994; 151: 198–205.

    Article  CAS  Google Scholar 

  15. Wei M et al. Total cholesterol and high density lipoprotein cholesterol as important predictors of erectile dysfunction. Am J Epidemiol 1994; 140: 930–937.

    Article  CAS  Google Scholar 

  16. Manning M et al. The role of blood lipids in erectile failure. Int J Impotence Res 1996; 8: 167 (D179).

    Google Scholar 

  17. Kim SC . Hyperlipidemia and erectile dysfunction. Asian J Androl 2000; 2: 161–166.

    CAS  PubMed  Google Scholar 

  18. Atahan O, Kayigil O, Hizel N, Metin A . Is apolipoprotein-(a) an important indicator of vasculogenic erectile dysfunction? Int Urol Nephrol 1998; 30: 185–191.

    Article  CAS  Google Scholar 

  19. Walczak MK, Lokhandwala N, Hodge MB, Guay AT . Prevalence of cardiovascular risk factors in erectile dysfunction. J Gend Specif Med 2002; 5: 19–24.

    PubMed  Google Scholar 

  20. Sanchez-Cruz JJ et al. Male erectile dysfunction and health-related quality of life. Eur Urol 2003; 44: 245–253.

    Article  CAS  Google Scholar 

  21. Feldman HA et al. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54–61.

    Article  CAS  Google Scholar 

  22. Pinnock CB, Stapleton AM, Marshall VR . Erectile dysfunction in the community: a prevalence study. Med J Aust 1999; 171: 353–357.

    CAS  PubMed  Google Scholar 

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Correspondence to M Nikoobakht.

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Nikoobakht, M., Nasseh, H. & Pourkasmaee, M. The relationship between lipid profile and erectile dysfunction. Int J Impot Res 17, 523–526 (2005).

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  • erectile dysfunction
  • lipids
  • cholesterol
  • LDL

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