Abstract
Bone marrow-derived endothelial progenitor cells (EPCs) originate from haematopoietic stem cells in bone marrow and migrate into the peripheral circulation to promote endothelial repair and neovascularization. The number of circulating progenitor cells is reduced in patients with cardiovascular risk factor. The aim of our study was to determine the number of these cells in healthy patients and to evaluate the effect of Vardenfil, a phosphodiesterases-5 (PDE-5) inhibitor, in the number of circulating EPCs. In our study, we found a significant increase in the number of these cells after the drug administration.
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References
Dimmeler S, Zeiher AM . Vascular repair by circulating endothelial progenitor cells: the missing link in atherosclerosis? J Mol Med 2004; 82: 671–677.
Aicher A, Heeschen C, Dimmeler S . The role of NOS3 in stem cell mobilization. Trends Mol Med 2004; 10: 421–425.
Aicher A et al. Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med 2003; 9: 1370–1376.
Foresta C et al. Circulating endothelial progenitor cells in subjects with erectile dysfunction. Int J Impot Res; E-pub ahead of print: 24 February 2005; doi:10.1038/sj.ijir.3901311.
Morelli A et al. Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa. Endocrinology 2004; 145: 2253–2263.
Shim HJ et al. Subacute toxicities and toxicokinetics of DA-8159, a new phosphodiesterase type V inhibitor, after single and 4-week repeated oral administration in rats. Biopharm Drug Dispos 2003; 24: 409–418.
Scheubel RJ et al. Age-dependent depression in circulating endothelial progenitor cells in patients undergoing coronary artery bypass grafting. J Am Coll Cardiol 2003; 42: 2073–2080.
Kukreja RC et al. Cardioprotection with phosphodiesterase-5 inhibition—a novel preconditioning strategy. J Mol Cell Cardiol 2004; 36: 165–173.
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Foresta, C., Lana, A., Cabrelle, A. et al. PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans. Int J Impot Res 17, 377–380 (2005). https://doi.org/10.1038/sj.ijir.3901325
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DOI: https://doi.org/10.1038/sj.ijir.3901325
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