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Efficacy of sildenafil as the first-step therapeutic tool for Japanese patients with erectile dysfunction

International Journal of Impotence Research volume 17, pages 339–342 (2005)Cite this article

Abstract

The aim of this study was to assess the efficacy of sildenafil as the first-step tool for erectile dysfunction (ED) in Japanese males. Between March 1999 and March 2003, 281 patients were prescribed five tablets of sildenafil (50 mg) as the first step in the therapeutic management of ED. Of the 281 patients, 206 were evaluable patients. The overall success rate in achieving sexual intercourse in subjects after taking sildenafil was 77.2% (159/206), while 22.8% (47/206) were unsuccessful. The success rates in men with functional ED and organic ED were 91.4% (85/93) and 65.5% (74/113), respectively (P<0.0001). Overall, transient adverse effects of sildenafil occurred in 16 (8%) males. Intolerable adverse effects (edema and dizziness) occurred in only 1% of patients (2/206). Sildenafil citrate may be recommended as the first choice drug for ED because of its high success rate and low invasiveness.

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References

  1. Benchekroun A et al. A baseline-controlled, open label, flexible dose-escalation study to assess the safety and efficacy of sildenafil citrate (Viagra) in patients with erectile dysfunction. Int J Impot Res 2003; 15 (Suppl 1): 19–24.

    Article  Google Scholar 

  2. Naya Y et al. The erythrocyte aldose reductase is a useful modality for predicting erectile dysfunction in diabetic patients. Int J Impot Res 2002; 14: 213–216.

    Article  CAS  Google Scholar 

  3. Rosen RC et al. Development and evaluation of abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction. Int J Impot Res 1999; 11: 319–326.

    Article  CAS  Google Scholar 

  4. Rosen RC, Cappelleri JC, Gendrano III N . The International Index of Erectile Function (IIEF): a state-of-the-science review. Int J Impot Res 2002; 14: 226–244.

    Article  CAS  Google Scholar 

  5. Shirai M . Epidemiology and risk factor of ED. Rinsho Kenkyu 1999; 76: 841–843.

    Google Scholar 

  6. Shirai M et al. A stockastic survey of impotence population in Japan. Impotence 1987; 2: 67–93.

    Google Scholar 

  7. Health and Welfare Statistics Association. Chapter 2 in Kokumin-eisei no doukou. J Health Welfare Stati 2000; 47: 37–42.

  8. Marumo K, Nakashima J, Murai M . Age-related prevalence of erectile dysfunction in Japan: assessment by the International Index of Erectile dysfunction. Int J Urol 2001; 8: 53–59.

    Article  CAS  Google Scholar 

  9. Naya Y et al. Preliminaly report of association of chronic diseases and erectile dysfunction in middle-aged men in Japan. Urology 2003; 62: 532–536.

    Article  Google Scholar 

  10. Takei M . Change of ED clinic. Jpn J Imp Res 2000; 15: 61.

    Google Scholar 

  11. McCullough AR et al. Achieving treatment optimization with sildenafil citrate (Viagra) in patients with erectile dysfunction. Urology 2002; 60 (Suppl 2): 28–38.

    Article  Google Scholar 

  12. Gresser U, Gleiter H . Erectile dysfunction: comparison of efficacy and side effect of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil—review of the literature. Eur J Med Res 2002; 29: 435–446.

    Google Scholar 

  13. Rendell MS, Rajfer J, Wicker PA, Smith MD . Sildenafil for treatment of erectile dysfunction in men with diabetes: a randomized controlled trial. Sildenafil Diabetes Study Group. JAMA 1999; 281: 421–426.

    Article  CAS  Google Scholar 

  14. Tan HL . Economic cost of male erectile dysfunction using a decision analytic model: for a hypothetical managed-care plan of 100,000 members. Pharmacoeconomics 2000; 17: 77–107.

    Article  CAS  Google Scholar 

  15. Lue TF . Physiology of penile erection and pathophysiology of erectile dysfunction and priapism. In: Walsh PC, Retik AB, Vaughan ED, Wein AJ (eds). Campbell's Urology 8thedn. Saunders: Philadelphia, 2002, pp 1591–1618.

    Google Scholar 

  16. Hsieh JT, Muller SC, Lue TF . The influence of blood flow and blood pressure on penile erection. Int J Impot Res 1989; 1: 35–42.

    Google Scholar 

  17. Ragazzi E et al. Characterization of in vitro relaxant mechanisms in erectile tissue from rabbits of different ages. Urol Res 1996; 24: 317–322.

    Article  CAS  Google Scholar 

  18. Goldstein I et al. Oral sildenafil in the treatment of erectile dysfunction. N Eng J Med. 1998; 338: 1397–1404.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Urology, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan

    A Ochiai, Y Naya, J Soh, Y Mizutani, A Kawauchi & T Miki

  2. Department of Urology, Matsushita Memorial Hospital, Moriguchi, Japan

    Y Naya

  3. Department of Urology, Rakuwakai-Marutamachi Hospital, Kyoto, Japan

    Y Ishida

  4. Fujiwara Urological Clinic, Kyoto, Japan

    T Fujiwara

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  1. A Ochiai
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  2. Y Naya
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  4. Y Ishida
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  5. Y Mizutani
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  6. A Kawauchi
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  7. T Fujiwara
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  8. T Miki
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Correspondence to Y Mizutani.

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Ochiai, A., Naya, Y., Soh, J. et al. Efficacy of sildenafil as the first-step therapeutic tool for Japanese patients with erectile dysfunction. Int J Impot Res 17, 339–342 (2005). https://doi.org/10.1038/sj.ijir.3901318

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  • DOI: https://doi.org/10.1038/sj.ijir.3901318

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