Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Research
  • Published:

The metabolic syndrome: a cause of sexual dysfunction in women

Abstract

Female sexual dysfunction (FSD) is a significant public health problem. We assessed the prevalence of FSD in premenopausal women with the metabolic syndrome as compared to the general female population. Compared with the control group (N=80), women with the metabolic syndrome (N=120) had reduced mean full Female Sexual Function Index (FSFI) score (23.2±5.4 vs 30.1±4.7, P<0.001), reduced satisfaction rate (3.5±1.1 vs 4.7±1.2, P<0.01), and higher circulating levels of C-reactive protein (CRP: 2.2 (0.6/4.9) vs 0.8 (0.2/2.9) mg/l, median (interquartile range), P=0.01). There was an inverse relation between CRP levels and FSFI score (r=−0.32, P=0.02). Investigation of female sexuality is suggested for patients with the metabolic syndrome.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Laumann EO, Paik A, Rosen RC . Sexual dysfunction in the United States. Prevalence and predictors. JAMA 1999; 281: 537–544.

    Article  CAS  Google Scholar 

  2. Rosen RC et al. The Female Sexual Function Index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000; 26: 191–208.

    Article  CAS  Google Scholar 

  3. Brody S . Slimness is associated with greater intercourse and lesser masturbation frequency. J Sex Marital Ther 2004; 30: 251–261.

    Article  Google Scholar 

  4. Enzlin P et al. Prevalence and predictors of sexual dysfunction in patients with type 1 diabetes. Diabetes Care 2003; 26: 409–414.

    Article  Google Scholar 

  5. Feldman HA et al. Impotence and its medical and psychological correlates: results of the Massachusetts Male Aging study. Int J Epidemiol 1994; 29: 524–531.

    Google Scholar 

  6. Esposito K et al. Effect of lifestyle changes on erectile dysfunction in obese men. A randomized controlled trial. JAMA 2004; 291: 2978–2984.

    Article  CAS  Google Scholar 

  7. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001; 285: 2486–2497.

  8. Cellek S, Moncada S . Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit. Br J Pharmacol 1998; 125: 1627–1629.

    Article  CAS  Google Scholar 

  9. Kim SW et al. Role of the nitric oxide cyclic GMP pathway in regulation of vaginal blood flow. Int J Impot Res 2003; 15: 355–361.

    Article  CAS  Google Scholar 

  10. Caruso S et al. The function of sildenafil on female sexual pathways: a double-blind, cross-over, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol 2003; 110: 201–206.

    Article  CAS  Google Scholar 

  11. Verma S et al. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 2002; 106: 913–919.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K Esposito.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Esposito, K., Ciotola, M., Marfella, R. et al. The metabolic syndrome: a cause of sexual dysfunction in women. Int J Impot Res 17, 224–226 (2005). https://doi.org/10.1038/sj.ijir.3901310

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.ijir.3901310

Keywords

This article is cited by

Search

Quick links