We investigated hypothesis that uterine erection, elevation and enlargement during sexual response are reflex and result from penis buffeting the glans clitoris (GC). In 23 healthy women, two recording electrodes were applied to the uterine mucosa and one to cervix uteri (CU). GC was stimulated electrically and mechanically by pencil electrode. The uterine and CU pressures were measured. Tests were repeated after anesthetization of the uterus or GC. Uterine electrodes recorded slow waves, followed by random bursts of action potentials (APs). No waves registered from CU. Electrical or mechanical GC stimulation eliminated uterine electric waves, but anesthetized GC did not, nor did GC stimulation while the uterus anesthetized. Uterine pressure declined on electrical or mechanical stimulation. Results suggest presence of reproducible reflex relationship between GC and the uterus, we call ‘clitorouterine reflex’. GC buffeting seems to evoke reflex and initiate uterine responses. Reflex may prove of diagnostic significance in sexual disorders.
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Bors E, Comarr AE . Neurological disturbances of sexual function with special reference to 629 patients with spinal cord injury. Urol Surv 1960; 10: 191–222.
Janig W . Behavioral and neurovegetative components of reproductive functions. In: Greger R, Windhorst U (eds). Comprehensive Human Physiology: From Cellular Mechanism to Integration. Springer-Verlag: New York, 1996, pp 2253–2263.
Masters WH, Johnson VE In: Masters WH, Johnson VE (eds). Human Sexual Response. Churchill Livingstone: London, 1970, p 26.
Pohl CR, Knobil E . The role of the central nervous system in the control of ovarian function in higher primates. Ann Rev Physiol 1982; 44: 583–585.
Shafik A . The cervico-cavernosus reflex. Description of the reflex and its role in the sexual act. Int Urogynecol J 1993a; 4: 70–73.
Shafik A . Vagino-cavernosus reflex. Clinical significance and role in sexual act. Gynec Obstet Invest 1993b; 35: 114–117.
Janig W, Mclachlan EM . Organization of lumbar spine outflow to the distal colon and pelvic organs. Physiol Rev 1987; 67: 1332–1404.
Bancroft J . The biological base of human sexuality. In: Bancroft J (ed). Human Sexuality and Its Problems, 2nd edn. Churchill Livingstone: London, p 63.
Bell C . Autonomic nervous control of reproduction: circulatory and other factors. Pharmacol Rev 1972; 24: 657–713.
Papka RE, Traurig HH . Autonomic efferent and visceral sensory innervation of the female reproductive system: special reference to neurochemical markers in nerves and ganglionic connections. In: Maggi CA (ed). Nervous Control of the Urogenital System. Harwood Academic: Chur, Switzerland, 1993, pp 423–466.
Traurig HH, Papka RE . Autonomic efferent and visceral sensory innervation of the female reproductive system: special reference to the functional roles of nerves in reproductive organs. In: Maggi CA (ed). Nervous Control of the Urogenital System. Harwood Academic: Chur, Switzerland, 1993, pp 103–141.
Morris JL, Gibbins IL . Co-transmission and neuromodulation. In: Burnstock G, Hoyle CHV (eds). Autonomic Neuroeffector Mechanism. Harwood Academic: Chur, Switzerland, 1992, pp 33–119.
Shafik A . Vagino-levator reflex: description of a reflex and its role in sexual performance. Eur J Obstet Gynecol 1995; 60: 161–164.
Shafik A . The ‘clitoromotor’ reflex. Int Urogynecol J 1995; 6: 329–336.
Shafik A . Electrohysterogram: study of the electromechanical activity of the uterus in humans. Eur J Obstet Gynecol Reprod Biol 1997; 73: 85–89.
Dapoigny M, Trolese JF, Bommerlae G, Tourrut R . Myoelectric spiking activity of right colon, left colon and rectosigmoid of healthy humans. Dig Dis Sci 1988; 33: 1007–1012.
Frexinos J, Bueno L, Fioramonti J . Diurnal changes in myoelectric spiking activity of the human colon. Gastroenterology 1985; 88: 1104–1110.
Garcia D et al. Colonic motility: electric and manometric description of mass movement. Dis Colon Rectum 1991; 34: 577–584.
Geldof H, Van der Schee EJ, Van Blankenstein M, Grashuis JL . Electrogastrographic study of gastric myoelectrical activity in patients with unexplained nausea and vomiting. Gut 1986; 27: 799–808.
Shafik A . Study of the electrical and mechanical activity of the rectum. Experimental study. Eur Surg Res 1994; 26: 87–93.
Shafik A . Electrorectography in chronic constipation. World J Surg 1995; 19: 772–775.
Shafik A . On the origin of the rectal electric waves: Further study. Dis Colon Rectum 1999; 42: 1626–1631.
Ward SM . Interstitial cells of Cajal in enteric neurotransmission. Gut 2000; 47(Suppl): 40–43.
Daniel EE et al. Do gap junctions couple interstitial cells of Cajal pacing and neurotransmission to gastrointestinal smooth muscle? Neurogastroenterol Motil 2001; 13: 297–307.
Liu LWC, Thuneberg L, Huizinga JD . Selective lesioning of interstitial cells of Cajal by methylene blue and light leads to loss of slow waves. Am J Physiol 1994; 266: 485–496.
Yokoyama O et al. Diagnostic value of intravesical lidocaine for overactive bladder. J Urol 2000; 164: 340–343.
Bancroft J . The biological basis of human sexuality. In: Bancroft J (ed). Human Sexuality and Its Problems 2nd edn. Churchill Livingstone: London, 1989, pp 38–44.
Wincze J, Hoon E, Hoon P . Physiological responsibility of normal and sexual dysfunctional women during erotic stimulus exposure. J Psychosom Res 1976; 20: 451–455.
Wincze J, Hoon E, Hoon P . Multiple measure analysis of women experiencing low sexual arousal. Behav Res Ther 1978; 16: 43–49.
Morokoff P, Heiman J . Effects of erotic stimulation on sexually functional and dysfunctional women: multiple measures before and after sex therapy. Behav Res Ther 1980; 18: 127–137.
Margot Yehia assisted in preparing the manuscript.
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Shafik, A., El-Sibai, O., Mostafa, R. et al. Response of the internal reproductive organs to clitoral stimulation: The clitorouterine reflex. Int J Impot Res 17, 121–126 (2005) doi:10.1038/sj.ijir.3901278
- cervix uteri
- slow waves
- action potentials
- sexual disorders
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