Abstract
Sexually potent and sluggish/impotent male rats were orally treated with an extract of Ferula hermonis (30 and 60 mg/kg). The acute administration stimulated sexual motivation in potent rats and improved copulatory performance in sluggish/impotent rats. This last effect was elicited only by the higher dose, which, in parallel, increased serum testosterone levels in rats. On the contrary, when the extract was subchronically administered (10 days) a marked reduction in the percentage of rats achieving ejaculation was detected, together with a general impairment of the copulatory pattern. Furthermore, the repeated administration of the extract (6 mg/kg/day for 10 days) resulted in a significant reduction of testosterone levels in comparison with controls. The present results discourage a repeated assumption of F. hermonis, while suggesting its acute administration to improve the performance in sexual dysfunctions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 8 print issues and online access
$259.00 per year
only $32.38 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Moreland RB, Hsieh G, Nakane M, Brioni JD . The biochemical and neurologic basis for the treatment of male erectile dysfunction. J Pharmacol Exp Ther 2001; 296: 225–234.
Hollister LE . The mystique of social drugs and sex. In: Sandler M, Gessa GL (eds). Sexual Behavior: Pharmacology and Biochemistry. Raven Press: New York, 1975, pp 85–92.
Kirkorian A . Khat and its use: a historical perspective. J Ethnopharmacol 1984; 12: 115–178.
Galal A . Sesquiterpenes from Ferula hermonis Boiss. Pharmazie 2000; 55: 961–962.
Abourashed EA, Galal AM, El-Feraly FS, Khan IA . Separation and quantification of the major daucane esters of Ferula hermonis by HPLC. Planta Med 2001; 67: 681–682.
El-Thaher TS, Matalka KZ, Taha HA, Badwan AA . Ferula harmonis “zallouh” and enhancing erectile function in rats: efficacy and toxicity study. Int J Impot Res 2001; 13: 247–251.
Dewsbury DA . Effects of tetrabenazine on the copulatory behavior of male rats. Eur J Pharmacol 1972; 17: 221–226.
Å gmo A . Male rat sexual behavior. Brain Res Prot 1997; 1: 203–209.
Beach FA . Characteristic of masculine “sex drive”. In: Jones MR (ed). Nebraska Symposium on Motivation. Press Lincoln: University of Nebraska, 1956, pp 1–31.
Murphy LL, Cadena RS, Chávez D, Ferraro JS . Effect of American Ginseng (Panax quinquefolium) on male copulatory behavior in the rat. Physiol behav 1998; 64: 445–450.
Gauthaman K, Adaikan PG, Prasad RNV . Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 2002; 71: 1385–1396.
Moundipa FP et al. Effects of acqueous extract of Hibiscus macranthus and Basella alba in mature rat testis function. J Ethnopharmacol 1999; 65: 133–139.
Khleifat K, Homady MH, Tarawneh KA, Shakhanbeh J . Effect of Ferula hormonis extract on social aggression fertility and some physiological parameters in prepubertal male mice. Endocr J 2001; 48: 473–482.
Homady MH, Khleifat KM, Tarawneh KA, Al-Raheil IA . Reproductive toxicity and infertility effect of Ferula hormonis extracts in mice. Theriogenology 2002; 57: 2247–2256.
Acknowledgements
We thank Indena Spa (Milano, Italy) for providing the F. hermonis extract used in this study and for financial support.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zanoli, P., Benelli, A., Rivasi, M. et al. Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male rats. Int J Impot Res 15, 450–455 (2003). https://doi.org/10.1038/sj.ijir.3901051
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.ijir.3901051
Keywords
This article is cited by
-
Effect of Selective Dorsal Neurectomy on Erectile Function in Rats
Current Medical Science (2023)
-
Herbal remedies used for the treatment of infertility in males and females by traditional healers in the rural areas of the West Bank/Palestine
BMC Complementary and Alternative Medicine (2019)
-
Paternal dapoxetine administration induced deterioration in reproductive performance, fetal outcome, sexual behavior and biochemistry of male rats
International Journal of Impotence Research (2015)
-
Synthesis and in vitro evaluation of ferutinol aryl esters for estrogenic activity and affinity toward cannabinoid receptors
Medicinal Chemistry Research (2015)
-
Activity of single components of Ferula hermonis on male rat sexual behavior
International Journal of Impotence Research (2005)