Abstract
The involvement of antihypertensive therapy in the pathology of hypertension associated male erectile dysfunction is unclear. Stroke prone spontaneously hypertensive rats (SHRSP) were treated chronically with the angiotensin converting enzyme (ACE) inhibitor captopril or placebo, normotensive rats served as controls. Mean arterial and intracavernosal pressure were measured during the induction of erection by autonomic ganglion stimulation. SHRSP-placebo treated rats were hypertensive and had a blunted erectile response. Captopril treatment returned both the blood pressure and erectile response to control levels. Therefore, ACE inhibitor therapy may not be responsible for the erectile dysfunction observed in treated hypertensive subjects.
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References
Bansal A . Sexual dysfunction in hypertensive men: A critical review of the literature Hypertension 1988; 12: 1–10.
Burchardt M et al. Hypertension is associated with severe erectile dysfunction J Urol 2000; 164: 1188–1191.
Feldman HA et al. Erectile dysfunction and coronary risk factors: prospective results form the Massachusetts male aging study Prev Med 2000; 30: 328–338.
Weiss RJ . Effects of antihypertensive agents on sexual function Am Fam Physician 1991; 44: 2075–2082.
Moss HB, Procci WR . Sexual dysfunction associated with oral antihypertensive medication: a critical survey of the literature Gen Hosp Psychiatry 1982; 4: 121–129.
Jensen J et al. The prevalence and etiology of impotence in 101 male hypertensive outpatients Am J Hypertens 1999; 23: 271–275.
Becker AJ et al. Possible role of bradykinin and Angiotensin II in the regulation of penile erection and detumescence Urology 2001; 57: 193–198.
Mills TM, Wiedmeier VT, Stopper VS . Androgen maintenance of erectile function in the rat penis Biol Reprod 1992; 46: 342–348.
Azadzoi KM et al. Hemodynamics of penile errection: III. Measurement of deep intracavernosal and suntunical blood flow and oxygen tension J Urol 1995; 159: 521–526.
Virag R, Bouilly P, Fryman D . Is impotence an arterial disorder? A study of arterial risk factors in 440 impotent men Lancet 1985; 1: 181–184.
Benson CB, Vickers MA . Sexual impotence caused by vascular disease: diagnosis with duplex sonography Am J Roent 1989; 153: 1149–1152.
Mulvany MJ et al. Vascular remodeling Hypertension 1996; 28: 505–506.
Chrysant SG . Vascular remodeling: The role of angiotensin converting enzyme inhibitors Am Heart J 1998; 135: S21–S30.
Srilatha B, Adaikan PG, Arulkumaran S, Ng SC . Sexual dysfunction related to antihypertensive agents: results from the animal model Int J Imp Res 1999; 11: 107–113.
Toblli JE et al. Morphological Changes in Cavernous tissue in spontaneously hypertensive rats Am J Hypertens 2000; 13: 686–692.
El Mabrouk M, Touyz RM, Schiffrin EL . Differential ANG II-induced growth activation pathways in mesenteric artery smooth muscle cells from SHR Am J Physiol 2001; 28: H30–H39.
Touyz RM et al. Src is an important mediator of extracellular signal-regulated kinase 1/2 - dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients Hypertension 2001; 38: 56–64.
Hale TM, Okabe H, Heaton JPW, Adams MA . Antihypertensive drugs induce structural remodeling of the penile vasculature J Urol 2001; 166: 739–745.
Kifor I et al. Tissue angiotensin II as a modulator of erectile function. I. Angiotensin peptide content, secretion and effects in the corpus cavernosum J Urol 1997; 157: 1920–1925.
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Dorrance, A., Lewis, R. & Mills, T. Captopril treatment reverses erectile dysfunction in male Stroke Prone Spontaneously Hypertensive Rats. Int J Impot Res 14, 494–497 (2002). https://doi.org/10.1038/sj.ijir.3900915
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DOI: https://doi.org/10.1038/sj.ijir.3900915
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