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Oral therapy for Peyronie's disease

International Journal of Impotence Research volume 14, pages 340–344 (2002)Cite this article

Abstract

Peyronie's disease (PD) remains a therapeutic dilemma for the urologist. Despite a myriad of medical therapies proposed for PD there have been limited advances in oral medical treatment. Several new approaches are presented which hold promise of success, although a definitive medical therapy for PD has yet to be established. Since early stage disease is reputed to respond better than well-established plaques, an early trial of inexpensive, safe and well-tolerated oral therapy is often initially recommended. This review discusses the historical aspects as well as contemporary oral medical therapy for PD. With advances in the molecular biology of inflammation and wound healing, the management and understanding of this frustrating disease will no doubt improve.

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References

  1. Lindsay MB et al. The incidence of Peyronie's Disease in Rochester, Minnesota, 1950 through 1984 J Urol 1991 146: 1007–1009

    Article  CAS  PubMed  Google Scholar 

  2. Carrieri MP et al. A case–control study on risk factors for Peyronie's disease J Clin Epidemiol 1998 51: 511–515

    Article  CAS  PubMed  Google Scholar 

  3. Devine CJ, Sommers KD, Jordan SG, Schlossberg SM . Proposal: trauma as the cause of the Peyronie's lesion J Urol 1997 157: 285–290

    Article  PubMed  Google Scholar 

  4. Lyles KW et al. Peyronie's disease is associated with Paget's disease of bone J Bone Miner Res 1997 12: 929–934

    Article  CAS  PubMed  Google Scholar 

  5. Wooldridge WE . Four related fibrosing diseases, when you find one, look for another Postgraduate Med 1988 84: 269–271

    Article  CAS  Google Scholar 

  6. Leffell MS . Is there an immunogenetic basis for Peyronie's disease? J Urol 1997 157: 295–297

    Article  CAS  PubMed  Google Scholar 

  7. Poley HJ . Induratio penis plastica Urol Cut Rev 1928 32: 287–308

    Google Scholar 

  8. Dunsmuir WD, Kirby RS . Francois de la Peyronie (1678–1747). The man and the disease he described Br J Urol 1996 78: 613–622

    Article  CAS  PubMed  Google Scholar 

  9. Blandy J . Penis and scrotum In: Blackwell, ed Urology Oxford Company: London 1976 pp 1083–1084

    Google Scholar 

  10. Chesney J . Peyronie's disease Br J Urol 1975 47: 209–218

    Article  CAS  PubMed  Google Scholar 

  11. Peacock EE . Pharmacological control of surgical scar tissue Am Surg 1978 44: 693–698

    PubMed  Google Scholar 

  12. Peacock EE . Pharmacologic control of surface scarring in human beings Ann Surg 1981 193: 592–597

    Article  PubMed  PubMed Central  Google Scholar 

  13. Smith BH . Peyronie's disease Am J Clin Path 1966 45: 670–676

    Article  CAS  PubMed  Google Scholar 

  14. Williams JL, Thomas GG . The natural history of Peyronie's disease J Urol 1970 103: 75–76

    Article  CAS  PubMed  Google Scholar 

  15. Furlow WL, Swenson HE, Lee RE . Peyronie's disease: a study of its natural history and treatment with orthovoltage radiotherapy J Urol 1979 114: 69

    Article  Google Scholar 

  16. Williams G, Green NA . The nonsurgical treatment of Peyronie's disease Br J Urol 1980 52: 392–395

    Article  CAS  PubMed  Google Scholar 

  17. Gelbard MK, Dorey F, James K . The natural history of Peyronie's disease J Urol 1990 1441: 376–379

    Google Scholar 

  18. Teloken C et al. Tamoxifen versus placebo in the treatment of Peyronie's disease J Urol 1999 162: 2003–2005

    Article  CAS  PubMed  Google Scholar 

  19. Scott WW, Scardino PL . New concept in treatment of Peyronie's disease South Med J 1947 41: 173–177

    Article  Google Scholar 

  20. Scardino PL, Scott WW . The use of tocopherols in the treatment of Peyronie's disease Ann NY Acad Sci 1949 52: 390–401

    Article  Google Scholar 

  21. Weissbach L, Widmann T . Zur Poblematik der Induratio penis plastical (IPP) In: IPP Symposium Aachen 1985 p 9

  22. Devine CJ Jr, Horton CE . Bent penis Semin Urol 1987 5: 251–261

    PubMed  Google Scholar 

  23. Hellstrom WJG, Bivalacqua TJ . Peyronie's disease: etiology, medical and surgical therapy J Androl 2000 21: 347–354

    CAS  PubMed  Google Scholar 

  24. Pryor JP, Farrell CR . Controlled clinical trial of vitamin E in Peyronie's disease Prog Reprod Biol Med 1983 9: 41–45

    Google Scholar 

  25. Zarafonetis CJD et al. Retrospective studies in scleroderma: skin response to potassium para-aminobenozate therapy Clin Exper Rheum 1988 6: 261–268

    CAS  Google Scholar 

  26. Griffiths MR, Priestly GC . A comparison of morphoea and lichen sclerosus et straphicus in vitro: The effects of para-aminobenzoate on skin fibroblasts Acta Derm Veneral 1992 72: 15–18

    CAS  Google Scholar 

  27. Priestly GC, Brown JC . Effects of potassium para-aminobenzoate on growth and macromolecule synthesis in fibroblasts cultured from normal and sclerodermatous human skin and rheumatoid synovial cells J Invest Dermatol 1979 72: 161–164

    Article  Google Scholar 

  28. Sagone AZ, Husney RM, Davis WB . Biotransformation of para-aminobenzoic acid and salicylic acid by PMN Free Radical Biol and Med 1993 14: 27–35

    Article  CAS  Google Scholar 

  29. Hasche-Klunder R . Treatment of induratio penis plastica Urologe 1970 6: 335–336

    Google Scholar 

  30. Carson CC . Potassium para-aminobenzoate for the treatment of Peyronie's disease: is it effective? Tech Urol 1997 3: 135–139

    CAS  PubMed  Google Scholar 

  31. Dominguez-Malagon HR, Alfeiran-Ruiz A, Chavarria-Xicontencatl P, Duran-Hernandez MS . Clinical and cellular effects of colchicine in fibromatosis Cancer 1992 69: 2478–2483

    Article  CAS  PubMed  Google Scholar 

  32. Ehrlich HP, Bornstein P . Microtubules in transcellular movement of procollagen Nature 1972 238: 257

    CAS  Google Scholar 

  33. Taylor AC . Microtubules in the microspikes and cortical cytoplasm of isolated cells J Cell Biol 1966 28: 155

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Kadioglu A et al. Treatment of Peyronie's disease with oral colchicine: long-term results and predictive parameters of successful outcome Int J Impot Res 2000 12: 169–175

    Article  CAS  PubMed  Google Scholar 

  35. Flores JJA et al. Results of the use of colchicine in the treatment of the tunica albuginea fibrosis J Androl 2001 22: (Suppl) 139

    Google Scholar 

  36. Anderson MS, Shankey TV, Lubrano T, Mulhall JP . Inhibition of Peyronie's plaque fibroblast proliferation by biologic agents Int J Impot Res 2000 12: S 25–31

    Article  Google Scholar 

  37. El-Sakka AI et al. The effects of colchicine on a Peyronie's-like condition in an animal model J Urol 1999 161: 1980–1983

    Article  CAS  PubMed  Google Scholar 

  38. Akkus E et al. Is colchicine effective in Peyronie's disease? A pilot study Urology 1994 44: 291–295

    Article  CAS  PubMed  Google Scholar 

  39. Ralph DJ, Brooks MD, Botazzi GF . The treatment of Peyronie's disease with tamoxifen Br J Urol 1995 75: 370–374

    Article  Google Scholar 

  40. Leopardi O et al. Immunohistochemical and quantitative study of mast cells in La Peyronie's disease Eur Urol 2000 37: 176–182

    Article  CAS  PubMed  Google Scholar 

  41. Zarafonetis CJD, Horrax TM . Treatment of Peyronie's disease with potassium para-aminobenzoate (Potaba) J Urol 1959 81: 770–774

    Article  CAS  PubMed  Google Scholar 

  42. Riley AJ . Peyronie's disease—a report on a series of 18 patients treated with potassium para-aminobenzoate Br J Sex Med 1979 6: 29–33

    Google Scholar 

  43. Hasche-Klunder R . Conservative treatment of Peyronie's disease with potassium para-aminobenzoate Prog Reprod Biol Med 1983 9: 57–64

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Urology, Mayo Clinic, Rochester, Minnesota, USA

    L A Mynderse

  2. Department of Urologic Surgery, University of Minnesota, USA

    M Monga

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  1. L A Mynderse
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  2. M Monga
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Correspondence to L A Mynderse.

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Mynderse, L., Monga, M. Oral therapy for Peyronie's disease. Int J Impot Res 14, 340–344 (2002). https://doi.org/10.1038/sj.ijir.3900869

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