Abstract
Peyronie's disease (PD) remains a therapeutic dilemma for the urologist. Despite a myriad of medical therapies proposed for PD there have been limited advances in oral medical treatment. Several new approaches are presented which hold promise of success, although a definitive medical therapy for PD has yet to be established. Since early stage disease is reputed to respond better than well-established plaques, an early trial of inexpensive, safe and well-tolerated oral therapy is often initially recommended. This review discusses the historical aspects as well as contemporary oral medical therapy for PD. With advances in the molecular biology of inflammation and wound healing, the management and understanding of this frustrating disease will no doubt improve.
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References
Lindsay MB et al. The incidence of Peyronie's Disease in Rochester, Minnesota, 1950 through 1984 J Urol 1991 146: 1007–1009
Carrieri MP et al. A case–control study on risk factors for Peyronie's disease J Clin Epidemiol 1998 51: 511–515
Devine CJ, Sommers KD, Jordan SG, Schlossberg SM . Proposal: trauma as the cause of the Peyronie's lesion J Urol 1997 157: 285–290
Lyles KW et al. Peyronie's disease is associated with Paget's disease of bone J Bone Miner Res 1997 12: 929–934
Wooldridge WE . Four related fibrosing diseases, when you find one, look for another Postgraduate Med 1988 84: 269–271
Leffell MS . Is there an immunogenetic basis for Peyronie's disease? J Urol 1997 157: 295–297
Poley HJ . Induratio penis plastica Urol Cut Rev 1928 32: 287–308
Dunsmuir WD, Kirby RS . Francois de la Peyronie (1678–1747). The man and the disease he described Br J Urol 1996 78: 613–622
Blandy J . Penis and scrotum In: Blackwell, ed Urology Oxford Company: London 1976 pp 1083–1084
Chesney J . Peyronie's disease Br J Urol 1975 47: 209–218
Peacock EE . Pharmacological control of surgical scar tissue Am Surg 1978 44: 693–698
Peacock EE . Pharmacologic control of surface scarring in human beings Ann Surg 1981 193: 592–597
Smith BH . Peyronie's disease Am J Clin Path 1966 45: 670–676
Williams JL, Thomas GG . The natural history of Peyronie's disease J Urol 1970 103: 75–76
Furlow WL, Swenson HE, Lee RE . Peyronie's disease: a study of its natural history and treatment with orthovoltage radiotherapy J Urol 1979 114: 69
Williams G, Green NA . The nonsurgical treatment of Peyronie's disease Br J Urol 1980 52: 392–395
Gelbard MK, Dorey F, James K . The natural history of Peyronie's disease J Urol 1990 1441: 376–379
Teloken C et al. Tamoxifen versus placebo in the treatment of Peyronie's disease J Urol 1999 162: 2003–2005
Scott WW, Scardino PL . New concept in treatment of Peyronie's disease South Med J 1947 41: 173–177
Scardino PL, Scott WW . The use of tocopherols in the treatment of Peyronie's disease Ann NY Acad Sci 1949 52: 390–401
Weissbach L, Widmann T . Zur Poblematik der Induratio penis plastical (IPP) In: IPP Symposium Aachen 1985 p 9
Devine CJ Jr, Horton CE . Bent penis Semin Urol 1987 5: 251–261
Hellstrom WJG, Bivalacqua TJ . Peyronie's disease: etiology, medical and surgical therapy J Androl 2000 21: 347–354
Pryor JP, Farrell CR . Controlled clinical trial of vitamin E in Peyronie's disease Prog Reprod Biol Med 1983 9: 41–45
Zarafonetis CJD et al. Retrospective studies in scleroderma: skin response to potassium para-aminobenozate therapy Clin Exper Rheum 1988 6: 261–268
Griffiths MR, Priestly GC . A comparison of morphoea and lichen sclerosus et straphicus in vitro: The effects of para-aminobenzoate on skin fibroblasts Acta Derm Veneral 1992 72: 15–18
Priestly GC, Brown JC . Effects of potassium para-aminobenzoate on growth and macromolecule synthesis in fibroblasts cultured from normal and sclerodermatous human skin and rheumatoid synovial cells J Invest Dermatol 1979 72: 161–164
Sagone AZ, Husney RM, Davis WB . Biotransformation of para-aminobenzoic acid and salicylic acid by PMN Free Radical Biol and Med 1993 14: 27–35
Hasche-Klunder R . Treatment of induratio penis plastica Urologe 1970 6: 335–336
Carson CC . Potassium para-aminobenzoate for the treatment of Peyronie's disease: is it effective? Tech Urol 1997 3: 135–139
Dominguez-Malagon HR, Alfeiran-Ruiz A, Chavarria-Xicontencatl P, Duran-Hernandez MS . Clinical and cellular effects of colchicine in fibromatosis Cancer 1992 69: 2478–2483
Ehrlich HP, Bornstein P . Microtubules in transcellular movement of procollagen Nature 1972 238: 257
Taylor AC . Microtubules in the microspikes and cortical cytoplasm of isolated cells J Cell Biol 1966 28: 155
Kadioglu A et al. Treatment of Peyronie's disease with oral colchicine: long-term results and predictive parameters of successful outcome Int J Impot Res 2000 12: 169–175
Flores JJA et al. Results of the use of colchicine in the treatment of the tunica albuginea fibrosis J Androl 2001 22: (Suppl) 139
Anderson MS, Shankey TV, Lubrano T, Mulhall JP . Inhibition of Peyronie's plaque fibroblast proliferation by biologic agents Int J Impot Res 2000 12: S 25–31
El-Sakka AI et al. The effects of colchicine on a Peyronie's-like condition in an animal model J Urol 1999 161: 1980–1983
Akkus E et al. Is colchicine effective in Peyronie's disease? A pilot study Urology 1994 44: 291–295
Ralph DJ, Brooks MD, Botazzi GF . The treatment of Peyronie's disease with tamoxifen Br J Urol 1995 75: 370–374
Leopardi O et al. Immunohistochemical and quantitative study of mast cells in La Peyronie's disease Eur Urol 2000 37: 176–182
Zarafonetis CJD, Horrax TM . Treatment of Peyronie's disease with potassium para-aminobenzoate (Potaba) J Urol 1959 81: 770–774
Riley AJ . Peyronie's disease—a report on a series of 18 patients treated with potassium para-aminobenzoate Br J Sex Med 1979 6: 29–33
Hasche-Klunder R . Conservative treatment of Peyronie's disease with potassium para-aminobenzoate Prog Reprod Biol Med 1983 9: 57–64
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Mynderse, L., Monga, M. Oral therapy for Peyronie's disease. Int J Impot Res 14, 340–344 (2002). https://doi.org/10.1038/sj.ijir.3900869
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DOI: https://doi.org/10.1038/sj.ijir.3900869
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