In several studies we have recently demonstrated that orgasm induces prolactin secretion in healthy males and females. This suggests that prolactin may form a feedback regulator of the refractory period following orgasm. To examine this position we investigated the prolactin response of a healthy multi-orgasmic male subject. Blood was drawn continuously during masturbation-induced orgasm. The prolactin response of the case-subject was compared with that of nine healthy adult men with a normal refractory period. The case-subject showed no prolactin response to three orgasms. Data from this multi-orgasmic subject support the hypothesized role of plasma prolactin in contributing to sexual-satiation mechanisms.
This is a preview of subscription content, access via your institution
Open Access articles citing this article.
Communications Biology Open Access 04 January 2021
Subscribe to Journal
Get full journal access for 1 year
only $14.88 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Get time limited or full article access on ReadCube.
All prices are NET prices.
Hummer M et al . Sexual disturbance during clozapine and haloperidol treatment for schizophrenia. Am J Psychiat 1999 156: 631–633.
Rosen RC, Lane RM, Menza M. . Effects of SSRIs on sexual function: a critical review. J Clin Psychopharm 1999 19: 67–85.
Krueger T et al . Neuroendocrine and cardiovascular response to sexual arousal and orgasm in men. Psychoneuroendocrinology 1998 23: 401–411.
Exton MS et al . Cardiovascular and endocrine alterations after masturbation-induced orgasm in women. Psychosom Med 1999 61: 280–289.
Exton MS et al . Coitus stimulates prolactin secretion in healthy subjects. Psychoneuroendocrinology 2001 26: 287–294.
Exton NG et al . Neuroendocrine response to film-induced sexual arousal in men and women. Psychoneuroendocrinology 2000 25: 187–199.
Dunn ME, Trost JE. . Male multiple orgasm: a descriptive study. Arch Sex Behav 1989 18: 377–387.
Krüger THC, Haake P, Hartmann U, Schedlowski M, Exton MS. . Prolactin release following orgasm: a feedback control of sexual arousal? Neurosci Biobehav Review 2002 26: 31–44
Koppelman MCS et al . Effect of Bromocriptine on affect and libido in hyperprolactinemia. Am J Psychiat 1987 144: 1037–1041.
Drago F, Lissandrello CO. . The ‘low dose’ concept and the paradoxical effects of prolactin on grooming and sexual behavior. Eur J Pharmacol 2000 405: 131–137.
The work contained in this manuscript was supported by a grant from the ‘Deutsche Forschungsgemeinschaft’ (Sche 341/10-1).
About this article
Cite this article
Haake, P., Exton, M., Haverkamp, J. et al. Absence of orgasm-induced prolactin secretion in a healthy multi-orgasmic male subject. Int J Impot Res 14, 133–135 (2002). https://doi.org/10.1038/sj.ijir.3900823
- sexual arousal
- refractory period
This article is cited by
Communications Biology (2021)
Journal of Endocrinological Investigation (2014)
World Journal of Urology (2005)
International Journal of Impotence Research (2003)