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Treatment of Peyronie's disease with oral colchicine: long‐term results and predictive parameters of successful outcome

Abstract

As recent clinical and animal studies have indicated, colchicine, with its anti‐fibrotic, anti‐mitotic and anti‐inflammatory activities, has suppressive effects in the pathogenesis of Peyronie's disease.

Oral colchicine treatment was initiated in 60 Peyronie's patients during their acute phase (mean duration of disease: 5.7±4.3 months). Long‐term results, based on changes of subjective and objective criteria, were assessed and predictive factors of successful outcome were investigated. After a mean follow‐up of 10.7±4.7 months, the penile deformity improved in 30%, remained unchanged in 48.3% and deteriorated in 21.7%. Pain resolved in 95%. Best results were obtained in those with no risk factor for vascular disease, presenting during the initial 6 months of disease, degree of curvature <30°, no erectile dysfunction by history and positive response to combined injection and stimulation test.

In conclusion since tunica albuginea is affected as a whole in Peyronie's disease, systemic oral agents, such as colchicine, may be preferred in the early phase of the disease.

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Correspondence to A Kadioğlu.

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Kadioğlu, A., Tefekli, A., Köksal, T. et al. Treatment of Peyronie's disease with oral colchicine: long‐term results and predictive parameters of successful outcome. Int J Impot Res 12, 169–175 (2000). https://doi.org/10.1038/sj.ijir.3900519

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  • DOI: https://doi.org/10.1038/sj.ijir.3900519

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