Abstract
The amino termini of histones extend from the nucleosomal core and are modified by acetyltransferases and deacetylases during the cell cycle. These acetylation patterns may direct histone assembly and help regulate the unfolding and activity of genes.
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Acknowledgements
I thank A. Berk, J. Kadonaga, G. Felsenfeld, S. Rundlett and A. Carmen for comments.
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Grunstein, M. Histone acetylation in chromatin structure and transcription. Nature 389, 349–352 (1997). https://doi.org/10.1038/38664
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DOI: https://doi.org/10.1038/38664
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