Cutting complexity down to size

Article metrics

The proteasome is the most complex eukaryotic macromolecular assembly yet seen in fine detail. The structure reveals completely unexpected mechanisms by which the proteasome neatly chops up unwanted proteins for disposal or display to the immune system.

References

  1. 1

    Groll, M. et al. Nature 386, 463–471 (1997).

  2. 2

    Löwe, J. et al. Science 268, 533–539 (1995).

  3. 3

    Weissman, J. S., Sigler, P. B. & Horwich, A. L. Science 268, 523–524 (1995).

  4. 4

    Blake, C. C. F. et al. Nature 206, 757–761 (1965).

  5. 5

    Seemüller, E. et al. Science 268, 579–582 (1995).

  6. 6

    Brannigan, J. A. et al. Nature 378, 416–419 (1995).

  7. 7

    Yoshimura, T. et al. J. Struct. Biol. 111, 200–201 (1993).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.