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An endothelial receptor for oxidized low-density lipoprotein

Nature volume 386, pages 73–77 (1997)Cite this article

Abstract

Endothelial dysfunction or activation elicited by oxidatively modified low-density lipoprotein (Ox-LDL) has been implicated in the pathogenesis of atherosclerosis1–4, characterized by intimal thickening and lipid deposition in the arteries. Ox-LDL and its lipid constituents impair endothelial production of nitric oxide, and induce the endothelial expression of leukocyte adhesion molecules and smooth-muscle growth factors, which may be involved in atherogenesis5–7. Vascular endothelial cells in culture8,9 and in vivo10,11 internalize and degrade Ox-LDL through a putative receptor-mediated pathway that does not involve macrophage scavenger receptors12–15. Here we report the molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells. The cloned receptor is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs.

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Affiliations

  1. Department of Pharmacology and Faculty of Medicine, Kyoto University, Kyoto, 606, Japan

    Tatsuya Sawamura, Takuma Aoyama, Hajime Hoshikawa, Soichi Miwa & Tomoh Masaki

  2. Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Kyoto, 606, Japan

    Noriaki Kume, Hideaki Moriwaki & Toru Kita

  3. Department of Immunology, Chest Disease Research Institute, Kyoto University, Kyoto, 606, Japan

    Yuichi Aiba & Yoshimoto Katsura

  4. Japan Red Cross Saitama Branch, Yono, Saitama, 338, Japan

    Takeshi Tanaka

Authors
  1. Tatsuya Sawamura
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  2. Noriaki Kume
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  3. Takuma Aoyama
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  4. Hideaki Moriwaki
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  5. Hajime Hoshikawa
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  6. Yuichi Aiba
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  7. Takeshi Tanaka
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  8. Soichi Miwa
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  9. Yoshimoto Katsura
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  10. Toru Kita
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  11. Tomoh Masaki
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Sawamura, T., Kume, N., Aoyama, T. et al. An endothelial receptor for oxidized low-density lipoprotein. Nature 386, 73–77 (1997). https://doi.org/10.1038/386073a0

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