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Bcl-2 promotes regeneration of severed axons in mammalian CNS

Nature volume 385, pages 434–439 (1997)Cite this article

Abstract

Most neurons of the mammalian central nervous system (CNS) lose the ability to regenerate severed axons in vivo after a certain point in development1. At least part of this loss in regenerative potential is intrinsic to neurons2–4. Although embryonic retinal ganglion cells (RGCs) can grow axons into tectum of any age, most RGCs from older animals fail to extend axons into CNS tissue derived from donors of any age, including the embryonic tectum2. Here we report that the proto-oncogene bcl-2 plays a key role in this developmental change by promoting the growth and regeneration of retinal axons. This effect does not seem to be an indirect consequence of its well-known anti-apoptotic activity. Another anti-apoptotic drug, ZVAD, supported neuronal survival but did not promote axon regeneration in culture. This finding could lead to new strategies for the treatment of injuries to the CNS.

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Author notes

  1. Jean-Claude Martinou: Glaxo Institute for Molecular Biology, 14 Chemin des Aulx, plan-les-Ouates, 1228 Geneva, Switzerland

Affiliations

  1. Howard Hughes Medical Institute, Center for Learning and Memory, Center for Cancer Research

    Dong Feng Chen & Susumu Tonegawa

  2. Departments of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Dong Feng Chen & Susumu Tonegawa

  3. Departments of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Dong Feng Chen, Gerald E. Schneider & Susumu Tonegawa

Authors
  1. Dong Feng Chen
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  2. Gerald E. Schneider
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  3. Jean-Claude Martinou
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  4. Susumu Tonegawa
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Chen, D., Schneider, G., Martinou, JC. et al. Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature 385, 434–439 (1997). https://doi.org/10.1038/385434a0

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