Host factors and the pathogenesis of HIV-induced disease

Abstract

The level of human immunodeficiency virus (HIV) replication in patients reflects a balance between stimulatory and inhibitory host factors (particularly endogenous cytokines). New information concerning the cellular co-receptors for HIV and the cellular tropism of different strains of virus will advance our understanding of HIV-induced pathogenesis and suggests new therapeutic and preventive strategies.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Fauci, A. S. Science 262, 1011–1018 (1993).

  2. 2

    Levy, J. A. Microbiol. Rev. 57, 183–289 (1993).

  3. 3

    Daar, E. S., Moudgil, T., Meyer, R. D. & Ho, D. D. N. Engl. J. Med. 324, 961–964 (1991).

  4. 4

    Clark, S. J. et al. N. Engl. J. Med. 324, 954–960 (1991).

  5. 5

    Moore, J. P., Cao, Y., Ho, D. D. & Koup, R. A. J. Virol. 68, 5142–5155 (1994).

  6. 6

    Koup, R. A. et al. J. Virol. 68, 4650–4655 (1994).

  7. 7

    Pantaleo, G., Graziosi, C. & Fauci, A. S. N. Engl. J. Med. 328, 327–335 (1993).

  8. 8

    Pantaleo, G. et al. Nature 362, 355–358 (1993).

  9. 9

    Piatak, M. et al. Science 259, 1749–1754 (1993).

  10. 10

    Ho, D. D. et al. Nature 373, 123–126 (1995).

  11. 11

    Wei, X. et al. Nature 373, 117–122 (1995).

  12. 12

    Perelson, A. S., Neumann, A. U., Markowitz, M., Leonard, J. M. & Ho, D. D. Science 271, 1582–1586 (1996).

  13. 13

    Coffin, J. M. Science 267, 483–489 (1995).

  14. 14

    Mellors, J. W. et al. Science 272, 1167–1170 (1996).

  15. 15

    Wolfs, T. F., Nara, P. L. & Goudsmit, J. Chem. Immunol. 56, 1–33 (1993).

  16. 16

    Haynes, B. F., Pantaleo, G. & Fauci, A. S. Science 271, 324–328 (1996).

  17. 17

    Zack, J. A. et al. Cell 61, 213–222 (1990).

  18. 18

    Ascher, M. S., Sheppard, H. W., Krowka, J. F. & Bremermann, H. J. Adv. Exp. Med. Biol. 374, 203–210 (1995).

  19. 19

    Bukrinsky, M. I., Stanwick, T. L., Dempsey, M. P. & Stevenson, M. Science 254, 423–427 (1991).

  20. 20

    Folks, T. et al. J. Immunol. 136, 4049–4053 (1986).

  21. 21

    Claydon, E. J., Bennett, J., Gor, D. & Forster, S. M. AIDS 5, 113–114 (1991).

  22. 22

    Goletti, D. et al. J. Immunol. 157, 1271–1278 (1996).

  23. 23

    Heng, M. C., Heng, S. Y. & Allen, S. G. Lancet 343, 255–258 (1994).

  24. 24

    Israel-Biet, D., Cadranel, J. & Even, P. Am. Rev. Respir. Dis. 148, 1308–1312 (1993).

  25. 25

    Denis, M. & Ghadirian, E. Clin. Exp. Immunol. 97, 76–82 (1994).

  26. 26

    Whalen, C. et al. Am. J. Resp. Crit. Care Med. 151, 129–135 (1995).

  27. 27

    Pape, J. W., Jean, S. S., Ho, J. L., Hafner, A. & Johnson, W. D. Jr Lancet 342, 268–272 (1993).

  28. 28

    Quinn, T. C. et al. J. Am. Med. Soc. 257, 2617–2621 (1987).

  29. 29

    Nagelkerke, N. J. et al. AIDS 4, 743–747 (1990).

  30. 30

    Colebunders, R. L. & Latif, A. S. AIDS 5 (suppl. 1), S103–S112 (1991).

  31. 31

    Wachter, H. et al. Lancet 2, 1216–1217 (1986).

  32. 32

    Bentwich, Z., Kalinkovich, A. & Weisman, Z. Immunol. Today 16, 187–191 (1995).

  33. 33

    Brown, C. C. et al. J. Infect. Dis. 169, 975–980 (1994).

  34. 34

    Thea, D. M. et al. Ann. Intern. Med. 124, 757–762 (1996).

  35. 35

    Ho, D. D. Lancet 339, 1549 (1992).

  36. 36

    Staprans, S. I. et al. J. Exp. Med. 182, 1727–1737 (1995).

  37. 37

    Stanley, S. K. et al. N. Engl. J. Med. 334, 1222–1230 (1996).

  38. 38

    O'Brien, W. A. et al. Blood 86, 1082–1089 (1995).

  39. 39

    Paul, W. E. & Seder, R. A. Cell 76, 241–251 (1994).

  40. 40

    Poli, G. & Fauci, A. S. in Human Cytokines: Their Role in Disease and Therapy (eds Aggarwal, B. B. & Puri, R. K.) 421–449 (Blackwell Science, Cambridge, MA, 1995).

  41. 41

    Graziosi, C. et al. Science 265, 248–252 (1994).

  42. 42

    Mosmann, T. R. & Coffman, R. L. Annu. Rev. Immunol. 7, 145–173 (1989).

  43. 43

    Romagnani, S. J. Clin. Immunol. 15, 121–129 (1995).

  44. 44

    Clerici, M. & Shearer, G. M. Immunol. Today 14, 107–111 (1993).

  45. 45

    Clerici, M. & Shearer, G. M. Immunol. Today 15, 575–581 (1994).

  46. 46

    Maggi, E. et al. Science 265, 244–248 (1994).

  47. 47

    Folks, T. M., Justemant, J., Kinter, A., Dinarello, C. A. & Fauci, A. S. Science 238, 800–802 (1987).

  48. 48

    Kinter, A. L., Poli, G., Fox, L., Hardy, E. & Fauci, A. S. J. Immunol. 154, 2448–2459 (1995).

  49. 49

    Kinter, A. L. et al. Proc. Natl Acad. Sci. USA 93, 14076–14081 (1996).

  50. 50

    Weissman, D., Poli, G. & Fauci, A. S. AIDS Res. Hum. Retr. 10, 1199–1206 (1994).

  51. 51

    Lenardo, M. J. & Baltimore, D. Cell 58, 227–229 (1989).

  52. 52

    Duh, E. J., Maury, W. J., Folks, T. M., Fauci, A. S. & Rabson, A. B. Proc. Natl Acad. Sci. USA 86, 5974–5978 (1989).

  53. 53

    Poli, G. et al. J. Exp. Med. 172, 151–158 (1990).

  54. 54

    Walker, C. M., Moody, D. J., Stites, D. P. & Levy, J. A. Science 234, 1563–1566 (1986).

  55. 55

    Levy, J. A., Mackewicz, C. E. & Barker, E. Immunol. Today 17, 217–224 (1996).

  56. 56

    Barker, T. D., Weissman, D., Daucher, J. A., Roche, K. M. & Fauci, A. S. J. Immunol. 156, 4476–4483 (1996).

  57. 57

    Baier, M., Werner, A., Bannert, N., Metzner, K. & Kurth, R. Nature 378, 563 (1995).

  58. 58

    Cocchi, F. et al. Science 270, 1811–1815 (1995).

  59. 59

    Dragic, T. et al. Nature 381, 667–673 (1996).

  60. 60

    Moriuchi, H. et al. Proc. Natl Acad. Sci. USA (in the press).

  61. 61

    Baggiolini, M., Dewald, B. & Moser, B. Adv. Immunol. 55, 97–179 (1994).

  62. 62

    Cheng-Mayer, C., Seto, D., Tateno, M. & Levy, J. A. Science 240, 80–82 (1988).

  63. 63

    Connor, R. I., Mohri, H., Cao, Y. & Ho, D. D. J. Virol. 67, 1772–1777 (1993).

  64. 64

    Roos, M. T. et al. J. Infect. Dis. 165, 427–432 (1992).

  65. 65

    Zhu, T. et al. Science 261, 1179–1181 (1993).

  66. 66

    Tersmette, M. et al. Lancet (i), 983–985 (1989).

  67. 67

    Schuitemaker, H. et al. J. Virol. 66, 1354–1360 (1992).

  68. 68

    Collman, R. et al. J. Virol. 66, 7517–7521 (1992).

  69. 69

    Shibata, R. et al. J. Virol. 69, 4453–4462 (1995).

  70. 70

    Doranz, B. J. et al. Cell 85, 1149–1158 (1996).

  71. 71

    Cheng-Mayer, C. AIDS 4 (suppl. 1), S49–S56 (1990).

  72. 72

    Feng, Y., Broder, C. C., Kennedy, P. E. & Berger, E. A. Science 272, 872–877 (1996).

  73. 73

    Murphy, P. M. Cytokine Growth Fact. Rev. 7, 47–64 (1996).

  74. 74

    Choe, H. et al. Cell 85, 1135–1148 (1996).

  75. 75

    Deng, H. et al. Nature 381, 661–666 (1996).

  76. 76

    Alkhatib, G. et al. Science 272, 1955–1958 (1996).

  77. 77

    Bleul, C. C. et al. Nature 382, 829–833 (1996).

  78. 78

    Oberlin, E. et al. Nature 382, 833–835 (1996).

  79. 79

    Oravecz, T., Pall, M. & Norcross, M. A. J. Immunol. 157, 1329–1332 (1996).

  80. 80

    Rowland-Jones, S. et al. Nature Med. 1, 59–64 (1995).

  81. 81

    Clerici, M. et al. J. Infect. Dis. 165, 1012–1019 (1992).

  82. 82

    Paxton, W. A. et al. Nature Med. 2, 412–417 (1996).

  83. 83

    Liu, R. et al. Cell 86, 367–377 (1996).

  84. 84

    Samson, M. et al. Nature 382, 722–725 (1996).

  85. 85

    Dean, M. et al. Science 273, 1856–1861 (1996).

  86. 86

    Huang, Y. et al. Nature Med. 2, 1240–1243 (1996).

  87. 87

    Weiss, R. A. & Clapham, P. R. Nature 381, 647–648 (1996).

  88. 88

    Bates, P. Cell 86, 1–3 (1996).

  89. 89

    Maddon, P. J. et al. Cell 47, 333–348 (1986).

  90. 90

    Wu, L., et al. Nature 384, 179–183 (1996).

  91. 91

    Trkola, A. et al. Nature 384, 184–187 (1996).

  92. 92

    Lapham, C. K. et al. Science 274, 602–605 (1996).

  93. 93

    Cocchi, F. et al. Nature Med. 2, 1244–1247 (1996).

  94. 94

    Hill, C. M. & Littman, D. R. Nature 382, 668–669 (1996).

  95. 95

    Cornelissen, M. et al. J. Virol. 69, 1810–1818 (1995).

  96. 96

    Loetscher, P., Seitz, M., Baggiolini, M. & Moser, B. J. Exp. Med. 184, 569–577 (1996).

  97. 97

    Moore, J. P. & Koup, R. A. J. Exp. Med. 184, 311–313 (1996).

  98. 98

    Spijkerman, I. J. et al. AIDS 9, 1085–1092 (1995).

  99. 99

    van't Wout, A. B. et al. J. Clin. Invest. 94, 2060–2067 (1994).

  100. 100

    Spira, A. I. et al. J. Exp. Med. 183, 215–225 (1996).

  101. 101

    Steinman, R. M. Annu. Rev. Immunol. 9, 271–296 (1991).

  102. 102

    Schmidtmayerova, H., Sherry, B. & Bukrinsky, M. Nature 382, 767 (1996).

  103. 103

    Valentin, A., Albert, J., Fenyo, E. M. & Asjo, B. J. Virol. 68, 6684–6689 (1994).

  104. 104

    Pantaleo, G. et al. N. Engl. J. Med. 332, 209–216 (1995).

  105. 105

    Cao, Y., Qin, L., Zhang, L., Safrit, J. & Ho, D. D. N. Engl. J. Med. 332, 201–208 (1995).

  106. 106

    Embretson, J. et al. Nature 362, 359–362 (1993).

  107. 107

    Pantaleo, G. et al. Immunol. Rev. 140, 105–130 (1994).

  108. 108

    Nagasawa, T., Kikutani, H. & Kishimoto, T. Proc. Natl Acad. Sci. USA 91, 2305–2309 (1994).

  109. 109

    Nagasawa, T. et al. Nature 382, 635–638 (1996).

  110. 110

    Fultz, P. N. Clin. Infect. Dis. 17 (suppl. 1), S230–S235 (1993).

  111. 111

    Desrosiers, R. C. Annu. Rev. Immunol. 8, 557–578 (1990).

  112. 112

    Rahemtulla, A. et al. Nature 353, 180–184 (1991).

  113. 113

    Mascola, J. R. et al. J. Infect. Dis. 173, 340–348 (1996).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.