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wingless refines its own expression domain on the Drosophila wing margin

Nature volume 384, pages 72–74 (1996)Cite this article

An Erratum to this article was published on 12 December 1996

Abstract

THE imaginal discs of Drosophila, which give rise to the adult appendages, are patterned during a period of intense cell proliferation. The specification of differing regions occurs in some cases by subdividing the disc epithelium into lineage compart-ments1. However, in most cases precise boundaries are formed between different cell types without early compartmentalization2. One such boundary occurs between the wingless (wg)-expressing cells of the wing margin and the adjacent proneural cells, which give rise to margin sensory bristles. Here we show that this boundary arises in part by a mechanism of 'self-refinement', by which wingless protein (Wg) represses wg expression in adjacent cells. Cells unable to receive the Wg signal do not resolve the boundary between H>g-expressing and proneural cells.

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Authors and Affiliations

  1. Program for Neuroscience, University of Wisconsin, 250 N. Mills Street, Madison, Wisconsin, 53706, USA

    Eric J. Rulifson & Craig A. Micchelli

  2. Department of Zoology, University of Wisconsin, 250 N. Mills Street, Madison, Wisconsin, 53706, USA

    Eric J. Rulifson, Craig A. Micchelli & Seth S. Blair

  3. Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Jeffrey D. Axelrod & Norbert Perrimon

  4. Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA

    Norbert Perrimon

  5. Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts, 02115, USA

    Jeffrey D. Axelrod

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  1. Eric J. Rulifson
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  2. Craig A. Micchelli
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  4. Norbert Perrimon
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  5. Seth S. Blair
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Rulifson, E., Micchelli, C., Axelrod, J. et al. wingless refines its own expression domain on the Drosophila wing margin. Nature 384, 72–74 (1996). https://doi.org/10.1038/384072a0

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