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Functional diversity of helper T lymphocytes

Abstract

The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses. Defining the cellular and molecular mechanisms of helper-T-cell differentiation should lead to rational strategies for manipulating immune responses for prophylaxis and therapy.

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Abbas, A., Murphy, K. & Sher, A. Functional diversity of helper T lymphocytes. Nature 383, 787–793 (1996). https://doi.org/10.1038/383787a0

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