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Supercritical fluids as solvents for chemical and materials processing

Nature volume 383, pages 313–318 (1996)Cite this article

Abstract

Fluids near their critical point have dissolving power comparable to that of liquids, are much more compressible than dilute gases, and have transport properties intermediate between gas-and liquid-like. This unusual combination of physical properties can be advantageously exploited in environmentally benign separation and reaction processes, as well as for new kinds of materials processing.

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References

  1. Hannay, J. B. & Hogarth, J. Proc. R. Soc. Lond. A 29, 324–326 (1879).

    Article  Google Scholar 

  2. DeSimone, J. M., Guan, Z. & Elsbernd, C. S. Science 257, 945–947 (1992).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. DeSimone, J. M. et al. Science 265, 356–359 (1994).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Tom, J. W., Lim, G.-B., Debenedetti, P. G. & Prud'homme, R. K. in Supercritical Fluid Engineering Science: Fundamentals and Applications (eds Kiran, E. & Brennecke, J. F.) 238–257 (ACS Symp. Ser. 514, American Chemical Soc., Washington DC, 1993).

    Google Scholar 

  5. Dixon, D. J. & Johnston, K. P. J. Appl. Polym. Sci. 50, 1929–1942 (1993).

    Article  CAS  Google Scholar 

  6. Dillow, A. K. et al. Ind. Eng. Chem. Res. 35, 1801–1806 (1996).

    Article  CAS  Google Scholar 

  7. Zosel, K. Angew. Chem. Int. Edn Engl. 17, 702–709 (1978).

    Article  Google Scholar 

  8. Gearhart, J. A. & Garwin, L. Hydrocarbon Process. 55, 125–129 (1976).

    Google Scholar 

  9. Schaeffer, S. T., Zalkow, L. H. & Teja, A. S. Biotechnol. Bioeng. 34, 1357–1365 (1989).

    Article  CAS  PubMed  Google Scholar 

  10. McHugh, M. & Krukonis, V. Supercritical Fluid Extraction (Butterworth-Heinemann, Boston, 1994).

    Google Scholar 

  11. Brennecke, J. F. & Eckert, C. A. Am. Inst. Chem. Eng. J. 35, 1409–1427 (1989).

    Article  CAS  Google Scholar 

  12. Schneider, G. M. in Supercritical Fluids, Fundamentals for Application (eds Kiran, E. & Levelt Sengers, J. M. H.) 91–116, 739–760 (NATO ASI Ser. E, 273, Kluwer, Dordrecht, 1994).

    Book  Google Scholar 

  13. Kumar, S. K. & Johnston, K. P. J. Supercrit. Fluids 1, 15–22 (1988).

    Article  CAS  Google Scholar 

  14. Gurdial, G. S. & Foster, N. R. Ind. Eng. Chem. Res. 30, 575–580 (1991).

    Article  CAS  Google Scholar 

  15. Brunner, G. & Peter, S. Ger. Chem. Eng. 5, 181–195 (1982).

    Google Scholar 

  16. Schmitt, W. J. & Reid, R. C. Fluid Phase Equil. 32, 77–99 (1986).

    Article  CAS  Google Scholar 

  17. Brunner, E. J. Chem. Thermodyn. 17, 671–679 (1985).

    Article  CAS  Google Scholar 

  18. Gurdial, G. S., Macnaughton, S. J., Tomasko, D. L. & Foster, N. R. Ind. Eng. Chem. Res. 32, 1488–1497 (1993).

    Article  CAS  Google Scholar 

  19. Van Alsten, J. G. & Eckert, C. A. J. Chem. Eng. Data 38, 605–610 (1993).

    Article  CAS  Google Scholar 

  20. Levelt Sengers, J. M. H. in Supercritical Fluids, Fundamentals for Application (eds Kiran, E. & Levelt Sengers, J. M. H.) 3–38 (NATO ASI Ser. E, 273, Kluwer, Dordrecht, 1994).

    Book  Google Scholar 

  21. Sengers, J. V. & Levelt Sengers, J. M. H. Annu. Rev. Phys. Chem. 37, 189–222 (1986).

    Article  ADS  CAS  Google Scholar 

  22. Iwasaki, H. & Takhashi, M. J. Chem. Phys. 74, 1930–1943 (1981).

    Article  ADS  CAS  Google Scholar 

  23. Debenedetti, P. G. & Reid, R. C. Am. Inst. Chem. Eng. J. 32, 2034–2046 (1986).

    Article  CAS  Google Scholar 

  24. Swaid, I. & Schneider, G. M. Ber. Bunsenges. Phys. Chem. 83, 969–974 (1979).

    Article  CAS  Google Scholar 

  25. Petsche, I. B. & Debenedetti, P. G. J. Phys. Chem. 95, 386–399 (1991).

    Article  CAS  Google Scholar 

  26. Kiran, E. & Levelt Sengers, J. M. H. (eds) Supercritical Fluids. Fundamentals for Application 761–771 (NATO ASI Ser. E, 273, Kluwer, Dordrecht, 1994).

  27. Brennecke, J. F., Tomasko, D. L., Peshkin, J. & Eckert, C. A. Ind. Eng. Chem. Res. 29, 1682–1690 (1990).

    Article  CAS  Google Scholar 

  28. Sun, Y.-P., Bennett, G., Johnston, K. P. & Fox, M. A. J. Phys. Chem. 96, 1001–1007 (1992).

    Google Scholar 

  29. Ekart, M. P. et al. Am. Inst. Chem. Eng. J. 39, 235–248 (1993).

    Article  Google Scholar 

  30. Paulaitis, M. E., Krukonis, V. J. & Kurnik, R. T. J. Phys. Chem. 86, 4948–4951 (1982).

    Article  Google Scholar 

  31. Eckert, C. A., Ziger, D. H., Johnston, K. P. & Kim, S. J. J. Phys. Chem. 90, 2738–2746 (1986).

    Article  CAS  Google Scholar 

  32. Gates, J. A., Wood, R. H. & Quint, J. R. J. Phys. Chem. 86, 4948–4951 (1982).

    Article  CAS  Google Scholar 

  33. Wheeler, J. C. Ber. Bunsenges. Phys. Chem. 76, 308–318 (1972).

    CAS  Google Scholar 

  34. Kurnik, R. T. & Reid, R. C. Fluid Phase Equil. 8, 93–105 (1982).

    Article  CAS  Google Scholar 

  35. Chialvo, A. A. J. Phys. Chem. 97, 2740–2744 (1993).

    Article  CAS  Google Scholar 

  36. Kwiatkowski, J., Lisicki, Z. & Majewski, W. Ber. Bunsenges. Phys. Chem. 88, 865–875 (1984).

    Article  CAS  Google Scholar 

  37. Dong, D.-C. & Winnick, M. A. Can. J. Chem. 62, 2560–2565 (1984).

    Article  CAS  Google Scholar 

  38. Knutson, B. L., Tomasko, D. L., Eckert, C. A., Debenedetti, P. G. & Chialvo, A. A. in Supercritical Fluid Technology: Theoretical and Applied Approaches in Analytical Chemistry (eds Bright, F. V. & McNally, M. E. P.) 60–72 (ACS Symp. Ser. 488, American Chemical Soc., Washington DC, 1992).

    Book  Google Scholar 

  39. O'Brien, J. A., Randolph, T. W., Carlier, C. & Ganapathy, S. Am. Inst. Chem. Eng. J. 39, 1061–1071 (1993).

    Article  CAS  Google Scholar 

  40. Kim, S. & Johnston, K. P. Am. Inst. Chem. Eng. J. 33, 1603–1611 (1987).

    Article  CAS  Google Scholar 

  41. Yonker, C. R. & Smith, R. D. J. Phys. Chem. 92, 2374–2378 (1988).

    Article  CAS  Google Scholar 

  42. Phillips, D. J. & Brennecke, J. F. Ind. Eng. Chem. Res. 32, 943–951 (1993).

    Article  CAS  Google Scholar 

  43. Fulton, J. L., Yee, G. G. & Smith, R. D. J. Am. Chem. Soc. 113, 8327–8334 (1991).

    Article  CAS  Google Scholar 

  44. Gupta, R. M., Combes, J. R. & Johnston, K. P. J. Phys. Chem. 97, 707–715 (1993).

    Article  CAS  Google Scholar 

  45. Tomasko, D. L., Knutson, B. L., Pouillot, F., Liotta, C. L. & Eckert, C. A. J. Phys. Chem. 97, 11823–11834 (1993).

    Article  CAS  Google Scholar 

  46. Petsche, I. B. & Debenedetti, P. G. J. Chem. Phys. 91, 7075–7084 (1989).

    Article  ADS  CAS  Google Scholar 

  47. Chialvo, A. A. & Cummings, P. T. Am. Inst. Chem. Eng. J. 40, 1558–1573 (1994).

    Article  CAS  Google Scholar 

  48. Zhang, J., Lee, L. L. & Brennecke, J. F. J. Phys. Chem. 99, 9268–9277 (1995).

    Article  CAS  Google Scholar 

  49. Wu, R. S., Lee, L. L. & Cochran, H. D. Ind. Eng. Chem. Res. 29, 977–988 (1990).

    Article  CAS  Google Scholar 

  50. Tom, J. W. & Debenedetti, P. G. Ind. Eng. Chem. Res. 32, 2118–2128 (1993).

    Article  CAS  Google Scholar 

  51. McGuigan, D. B. & Monson, P. A. Fluid Phase Equil. 57, 227–247 (1990).

    Article  CAS  Google Scholar 

  52. Muñoz, F. & Chimowitz, E. H. Fluid Phase Equil. 71, 237–272 (1992).

    Article  Google Scholar 

  53. Cochran, H. D., Johnson, E. & Lee, L. L. J. Supercrit. Fluids 3, 157–161 (1990).

    Article  CAS  Google Scholar 

  54. Cummings, P. T., Chialvo, A. A. & Cochran, H. D. Chem. Eng. Sci. 49, 2735–2748 (1994).

    Article  CAS  Google Scholar 

  55. Cui, S. T. & Harris, J. G. Chem. Eng. Sci. 49, 2749–2763 (1994).

    Article  CAS  Google Scholar 

  56. Balbuena, P. B., Johnston, K. P. & Rossky, P. J. J. Am. Chem. Soc. 116, 2689–2690 (1994).

    Article  CAS  Google Scholar 

  57. Clifford, A. A. in Supercritical Fluids. Fundamentals for Application (eds Kiran, E. & Levelt Sengers, J. M. H.) 449–479 (NATO ASI Ser. E, 273, Kluwer, Dordrecht, 1994).

    Book  Google Scholar 

  58. Johnston, K. P. & Haynes, C. Am. Inst. Chem. Eng. J. 33, 2017–2026 (1987).

    Article  CAS  Google Scholar 

  59. Kim, S. & Johnston, K. P. Chem. Eng. Commun. 63, 49–59 (1988).

    Article  CAS  Google Scholar 

  60. Roberts, C. B., Chateauneuf, J. E. & Brennecke, J. F. J. Am. Chem. Soc. 114, 8455–8463 (1992).

    Article  CAS  Google Scholar 

  61. Ellington, J. B., Park, K. M. & Brennecke, J. F. Ind. Eng. Chem. Res. 33, 965–974 (1994).

    Article  CAS  Google Scholar 

  62. Randolph, T. W. & Carlier, C. J. Phys. Chem. 96, 5146–5151 (1992).

    Article  CAS  Google Scholar 

  63. Zagrobelny, J. A. & Bright, F. V. J. Am. Chem. Soc. 114, 7821–7826 (1992).

    Article  CAS  Google Scholar 

  64. O'Shea, K. E., Combes, J. R., Fox, M. A. & Johnston, K. P. Photochem. Photobiol. 54, 571–576 (1991).

    Article  CAS  Google Scholar 

  65. Roberts, C. B., Zhang, J., Chateauneuf, J. E. & Brennecke, J. F. J. Phys. Chem. 97, 5618–5623 (1993).

    Article  CAS  Google Scholar 

  66. Randolph, T. W., O'Brien, J. A. & Ganapathy, S. J. Phys. Chem. 98, 4173–4179 (1994).

    Article  CAS  Google Scholar 

  67. Kamat, S. V., Iwaskewycz, B., Beckman, E. J. & Russell, A. J. Proc. Natl. Acad. Sci. USA 90, 2940–2944 (1993).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  68. Chaudhary, A. K., Beckman, E. J. & Russell, A. J. J. Am. Chem. Soc. 117, 3728–3733 (1995).

    Article  CAS  Google Scholar 

  69. Yeo, S.-D., Debenedetti, P. G., Radosz, M. & Schmidt, H.-W. Macromolecules 26, 6207–5210 (1993).

    Article  ADS  CAS  Google Scholar 

  70. Winters, M. A. et al. J. Pharm. Sci. 85, 586–594 (1996).

    Article  CAS  PubMed  Google Scholar 

  71. Yeo, S.-D., Lim, G.-B., Debenedetti, P. G. & Bernstein, H. Biotechnol. Bioeng. 41, 341–346 (1993).

    Article  CAS  PubMed  Google Scholar 

  72. Yeo, S.-D., Debenedetti, P. G., Patro, S. Y. & Przybycien, T. M. J. Pharm. Sci. 83, 1651–1656 (1994).

    Article  CAS  PubMed  Google Scholar 

  73. Dixon, D. J., Johnston, K. P. & Bodemeier, R. A. Am. Inst. Chem. Eng. J. 39, 127–139 (1993).

    Article  CAS  Google Scholar 

  74. Tom, J. W. & Debenedetti, P. G. J. Aerosol Sci. 22, 555–584 (1991).

    Article  ADS  CAS  Google Scholar 

  75. Randolph, T. W., Randolph, A. D., Mebes, M. & Yeung, S. Biotechnol. Prog. 9, 429–435 (1993).

    Article  CAS  PubMed  Google Scholar 

  76. Dooley, K. M., Kao, C.-P., Gambrell, R. P. & Knopf, F. C. Ind. Eng. Chem. Res. 26, 2058–2062 (1987)

    Article  CAS  Google Scholar 

  77. Macnaughton, S. J. & Foster, N. R. Ind. Eng. Chem. Res. 34, 275–282 (1995).

    Article  CAS  Google Scholar 

  78. Shaw, R. W., Brill, T. B., Clifford, A. A., Eckert, C. A. & Franck, E. U. Chem. Eng. News 69 (51), 26–39 (1991).

    CAS  Google Scholar 

  79. Jessop, P. G., Hsiao, T., Ikariya, T. & Noyori, R. J. Am. Chem. Soc. 118, 344–345 (1996).

    Article  CAS  Google Scholar 

  80. Beckman, E. J. Science 271, 613–614 (1996).

    Article  ADS  CAS  Google Scholar 

  81. Johnston, K. P. et al. Science 271, 624–626 (1996).

    Article  ADS  CAS  Google Scholar 

  82. Kazarian, S. G., Vincent, M. F., Bright, F. V., Liotta, C. L. & Eckert, C. A. J. Am. Chem. Soc. 118, 1729–1736 (1996).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. School of Chemical Engineering and Specialty Separations Center, Georgia Institute of Technology, Atlanta, Georgia, 30332-0100, USA

    Charles A. Eckert

  2. Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky, 40506-0046, USA

    Barbara L. Knutson

  3. Department of Chemical Engineering, Princeton University, Princeton, New Jersey, 08544-5263, USA

    Pablo G. Debenedetti

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  1. Charles A. Eckert
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  2. Barbara L. Knutson
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  3. Pablo G. Debenedetti
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Eckert, C., Knutson, B. & Debenedetti, P. Supercritical fluids as solvents for chemical and materials processing. Nature 383, 313–318 (1996). https://doi.org/10.1038/383313a0

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