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Two-bit anion channel really shapes up

Naturevolume 383pages295296 (1996) | Download Citation

Subjects

Channels that conduct anions or cations across cell membranes are of immense physiological importance. But what do they look like? A chloride channel turns out to have a double-barrelled structure quite unlike that of cation channels.

References

  1. 1

    Hille, B. Ionic Channels of Excitable Membranes (Sinauer, Sunderland, MA, 1992).

  2. 2

    MacKinnon, R. Neuron 14, 889–892 (1995).

  3. 3

    Middleton, R. E., Pheasant, D. J. & Miller, C. Nature 383, 337–340 (1996).

  4. 4

    Ludewig, U., Pusch, M. & Jentsch, T. J. Nature 383, 340–343 (1996).

  5. 5

    Miller, C. & Richard, E. A. in Chloride Channels and Carriers in Nerve, Muscle, and Glial Cells (eds Alvarez-Leefmans, F. J. & Russell, J. M.) 383–405 (Plenum, New York, 1990).

  6. 6

    Middleton, R. E., Pheasant, D. J. & Miller, C. Biochemistry 33, 13189–13198 (1994).

  7. 7

    Steinmeyer, K., Lorenz, C., Pusch, M., Koch, M. C. & Jentsch, T. J. EMBO J. 13, 737–743 (1994).

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Author information

Affiliations

  1. Laboratory of Cardiac/Membrane Physiology, The Rockefeller University, 1230 York Avenue, New York, New York, 10021, USA

    • David C. Gadsby

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https://doi.org/10.1038/383295a0

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