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A genome-wide search for quantitative trait loci underlying asthma

Abstract

ASTHMA now affects one child in seven in the United Kingdom1. Most cases (95%) of childhood asthma are associated with atopy, the immunoglobulin E (IgE)-mediated familial syndrome of allergic asthma, eczema and rhinitis. Segregation analysis has consistently suggested the presence of major genes influencing atopy and IgE levels2–4, with the expectation that these genes may be identified by positional cloning or the examination of candidate genes. Here we report the results of a genome-wide search for linkage to one qualitative and four quantitative traits associated with allergic (atopic) asthma. We have identified six potential linkages (P < 0.001), five of which are to quantitative traits. Monte Carlo simulations show that 1.6 false-positive linkages at this level of significance would be expected from the data. One linkage, to chromosome Ilql3, has been established previously5. Three of the new loci show evidence of linkage to a second panel of families, in which maternal effects and pleiotropy of linked phenotypes are seen. The results demonstrate the extent and the complexity of the genetic predisposition to asthma.

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References

  1. 1

    Strachan, D. P., Anderson, H. R., Limb, E. S., O'Neill, A. & Wells, N. Arch. Dis. Child. 70, 174–178 (1994).

    CAS  Article  Google Scholar 

  2. 2

    Gerrard, J. W., Rao, D. C. & Morton, N. E. Am. J. Hum. Genet. 30, 46–58 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. 3

    Borecki, I., Rao, D. C., Lalouel, J. M., McGue, L. & Gerrard, J. W. Genet. Epidemiol. 2, 327–338 (1985).

    CAS  Article  Google Scholar 

  4. 4

    Dizier, M. H. et al. Genet. Epidemiol. 12, 93–105 (1995).

    CAS  Article  Google Scholar 

  5. 5

    Sandford, A. J. et al. Lancet 341, 332–334 (1993).

    CAS  Article  Google Scholar 

  6. 6

    O'Connor, G. T. & Weiss, S. T. Am. J. Respir. Crit. Care Med. 149, S21–28 (1994).

    CAS  Article  Google Scholar 

  7. 7

    Holford-Strevens, V. et al. J. Allergy Clin. Immunol. 73, 516–522 (1984).

    CAS  Article  Google Scholar 

  8. 8

    Peat, J. K., Brittoh, W. J., Salome, C. M. & Woolcock, A. J. Clin. Allergy 17, 271–281 (1987).

    Article  Google Scholar 

  9. 9

    Cline, M. G. & Burrows, B. B. Thorax 44, 425–432 (1989).

    CAS  Article  Google Scholar 

  10. 10

    Moffatt, M. F. et al. Clin. Exp. Allergy 22, 1046–1051 (1992).

    CAS  Article  Google Scholar 

  11. 11

    O'Connor, G., Sparrow, D., Taylor, D., Segal, M. & Weiss, S. Am. Rev. Respir. Dis. 136, 1412–1417 (1987).

    CAS  Article  Google Scholar 

  12. 12

    Cookson, W. O. C. M. & Hopkin, J. M. Lancet (i), 86–88 (1988).

  13. 13

    Young, R. P. et al. J. Med. Genet. 29, 236–238 (1992).

    CAS  Article  Google Scholar 

  14. 14

    Haseman, J. K. & Elston, R. C. Behav. Genet 2, 3–19 (1972).

    CAS  Article  Google Scholar 

  15. 15

    Reed, P. W. et al. Nature Genet 7, 390–395 (1994).

    CAS  Article  Google Scholar 

  16. 16

    Weissenbach, J. et al. Nature 359, 794–801 (1992).

    ADS  CAS  Article  Google Scholar 

  17. 17

    Magnusson, C. G. Allergy 43, 241–251 (1988).

    CAS  Article  Google Scholar 

  18. 18

    Halonen, M. et al. Am. Rev. Respir. Dis. 146, 866–870 (1992).

    CAS  Article  Google Scholar 

  19. 19

    Åberg, N. Clin. Exp. Allergy 23, 829–834 (1994).

    Article  Google Scholar 

  20. 20

    Kuehr, J. et al. Clin. Exp. Allergy 23, 600–605 (1993).

    CAS  Article  Google Scholar 

  21. 21

    Cookson, W. O. C. M., Sharp, P. A., Faux, J. A. & Hopkin, J. M. Lancet (i), 1292–1295 (1989).

  22. 22

    Shirakawa, T. et al. Clin. Genet 46, 125–129 (1994).

    Google Scholar 

  23. 23

    Collée, J. M. et al. Lancet 341, 936 (1993).

    Article  Google Scholar 

  24. 24

    Herwerden, L. et al. Lancet 346, 1262–1265 (1995).

    Article  Google Scholar 

  25. 25

    Eiberg, H., Lind, P., Mohr, J. & Nielsen, L. S. Cytogenet. Cell. Genet. 40, 622 (1985).

    Google Scholar 

  26. 26

    Marsh, D. G. et al. Science 264, 1152–1155 (1994).

    ADS  CAS  Article  Google Scholar 

  27. 27

    Myers, D. A. et al. Genomics 23, 464–470 (1994).

    Article  Google Scholar 

  28. 28

    Suarez, B. K., Hampe, C. L. & Van Eerdewegh, P. in Genetic Approaches to Mental Disorders (eds Gershon, E. S. & Cloninger, C. R.) 23–46 (American Psychiatric, Washington DC, 1994).

    Google Scholar 

  29. 29

    Hill, M. R. et al. BMJ 311, 776–779 (1995).

    CAS  Article  Google Scholar 

  30. 30

    Hodge, S. E. Genet. Epidemiol. 1, 109–122 (1984).

    CAS  Article  Google Scholar 

Download references

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Daniels, S., Bhattacharrya, S., James, A. et al. A genome-wide search for quantitative trait loci underlying asthma. Nature 383, 247–250 (1996). https://doi.org/10.1038/383247a0

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