The complicated machinery that initiates transcription of protein-coding genes contains components, known as TAFs, that are held to be generally required for gene activation. Experiments in vivo change that view.
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Chao, D., Young, R. Activation without a vital ingredient. Nature 383, 119–120 (1996). https://doi.org/10.1038/383119a0
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DOI: https://doi.org/10.1038/383119a0