A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

Nature volume 382, pages319–324(1996)Cite this article

Abstract

The adenoviral oncoprotein E1A induces progression through the cell cycle by binding to the products of the p300/CBP and retinoblastoma gene families. A new cellular p300/CBP-associated factor (P/CAF) having intrinsic histone acetylase activity has been identified that competes with E1A. Exogenous expression of P/CAF in HeLa cells inhibits cell-cycle progression and counteracts the mitogenic activity of E1A. E1A disturbs the normal cellular interaction between p300/CBP and its associated histone acetylase.

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Author notes

  1. Jun-ichi Nishikawa

    Present address: Department of Environmental Biochemistry, Faculty of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka, 565, Japan

Affiliations

  1. Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, 20892-2753, USA

    Xiang-Jiao Yang, Vasily V. Ogryzko, Jun-ichi Nishikawa, Bruce H. Howard & Yoshihiro Nakatani

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  1. Xiang-Jiao Yang
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  2. Vasily V. Ogryzko
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  3. Jun-ichi Nishikawa
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  4. Bruce H. Howard
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  5. Yoshihiro Nakatani
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Yang, XJ., Ogryzko, V., Nishikawa, Ji. et al. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382, 319–324 (1996). https://doi.org/10.1038/382319a0

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