Under arrest at atomic resolution

Cell proliferation in many tissues is regulated by p27 protein, which binds and inhibits cyclin-dependent kinases. A crystal structure reveals the remarkable mechanisms by which p27 paralyses these enzymes, arresting the cell cycle.

References

  1. 1

    Russo, A. A., Jeffrey, P. D., Patten, A. K., Massagué, J. & Pavletich, N. P. Nature 382, 325–331 (1996).

  2. 2

    Morgan, D. O. Nature 374, 131–134 (1995).

  3. 3

    Sherr, C. J. & Roberts, J. M. Genes Dev. 9, 1149–1163 (1995).

  4. 4

    Nakayama, K. et al. Cell 85, 707–720 (1996).

  5. 5

    Kiyokawa, H. et al. Cell 85, 721–732 (1996).

  6. 6

    Fero, M. L. et al. Cell 85, 733–744 (1996).

  7. 7

    De Bondt, H. L. et al. Nature 363, 595–602 (1993).

  8. 8

    Jeffrey, P. D. et al. Nature 376, 313–320 (1995).

  9. 9

    Russo, A. A., Jeffrey, P. D. & Pavletich, N. P. Nature Struct. Biol. 3, 696–700 (1996).

  10. 10

    Brown, N. R. et al. Structure 3, 1235–1247 (1996).

  11. 11

    Zhu, L. et al. Genes Dev. 9, 1740–1752 (1995).

  12. 12

    Zhang, H., Hannon, G. J. & Beach, D. Genes Dev. 8, 1750–1758 (1994).

  13. 13

    Harper, J. W. et al. Mol. Biol. Cell 6, 387–400 (1995).

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Morgan, D. Under arrest at atomic resolution. Nature 382, 295–296 (1996). https://doi.org/10.1038/382295a0

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