Abstract
THE question of whether nicotine, the neuroactive compound of tobacco, is addictive has been open to considerable scientific and public discussion. Although it can serve as a positive reinforcer in several animal species, including man, nicotine is thought to be a weak reinforcer in comparison with addictive drugs such as cocaine and heroin1,2, and has been argued to be habit forming but not addictive3,4. Here we report that intravenous nicotine in the rat, at doses known to maintain self-administration, stimulates local energy metabolism, as measured by 2-deoxyglucose autoradiography, and dopamine transmission, as estimated by brain microdialysis, in the shell of the nucleus accumbens. These neurochemical and metabolic effects are qualitatively similar to those of other drugs, such as cocaine, amphetamine and morphine, which have strong addictive properties5–7. Our results provide functional and neurochemical evidence that there are specific neurobiological commonalities between nicotine and addictive drugs.
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References
Stolerman, I. P. in Handbook of Psychopharmacology (eds Iversen, L. L, Iversen, L. D. & Snyder, S. H.) 421–465 (Plenum, New York, 1987).
Swedberg, M. D. B., Henningfield, J. E. & Goldberg, S. R. in Nicotine Psychopharmacology: Molecular, Cellular and Behavioral Aspects (eds Wonnacott, S., Russell, M. A. H. & Stolerman, I. P.) 38–76 (Oxford Science, Oxford, 1990).
Robinson, J. H. & Pritchards, W. S. Psychopharmacology 108, 397–407 (1992).
Warburton, D. M., Revell, A. & Walters, A. C. in The Pharmacology of Nicotine (eds Rand, M. & Thurau, K.) 359–373 (IRL, Oxford, 1989).
Pontieri, F. E. et al. NeuroReport 5, 2561–2564 (1994).
Orzi, F. et al. Eur. J. Pharmac. (in the press).
Pontieri, F. E., Tanda, G. & Di Chiara, G. Proc. natn. Acad. Sci. U.S.A. 92, 12304–12308 (1995).
Wise, R. A. & Bozarth, M. A. Psychol. Rev. 94, 469–492 (1987).
Koob, G. F. Trends pharmac. Sci. 13, 177–184 (1992).
Di Chiara, G. Drug Alcohol Depend. 38, 95–121 (1995).
Di Chiara, G. & Imperato, A. Proc. natn. Acad. Sci. U.S.A. 88, 5274–5278 (1988).
Alheid, G. F. & Heimer, L. Neuroscience 27, 1–39 (1988).
Heimer, L. et al. Neuroscience 41, 89–125 (1991).
Corrigall, W. A. & Coen, K. M. Psychopharmacology 99, 473–478 (1989).
Corrigall, W. A. in Effects of Nicotine on Biological Systems (eds Adklofer, F. & Thurau, K.) 423–432 (Birkhauser, Boston, 1991).
Sokoloff, L. et al. J. Neurochem. 28, 897–916 (1977).
Ungerstedt, U. in Measurement of Neurotransmitter Release in Vivo (ed. Marsden, C. A.) 81–105 (Wiley, Chichester, 1984).
Di Chiara, G. Trends pharmac. Sci. 11, 116–121 (1990).
London, E. D. et al. J. Neurosci. 8, 3920–3928 (1988).
McNamara, D. et al. J. cerebr. Blood Flow Metab. 10, 48–56 (1990).
Grunwald, F., Schrock, H. & Kuschinsky, W. Brain Res. 400, 232–238 (1987).
Porrino, L. J. Psychopharmacology 112, 343–351 (1993).
Imperato, A., Mulas, A. & Di Chiara, G. Eur. J. Pharmac. 132, 337–338 (1986).
Damsma, G., Day, J. & Fibiger, N. C. Eur. J. Pharmac. 168, 368–371 (1989).
Henningfield, J. E. & Heishman, S. J. Psychopharmacology 117, 11–13 (1995).
Tiffany, S. T. Psychol. Rev. 97, 147–168 (1990).
Crane, A. M. & Porrino, L J. Brain Res. 499, 87–92 (1989).
Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates (Academic, Sydney, 1987).
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Pontieri, F., Tanda, G., Orzi, F. et al. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature 382, 255–257 (1996). https://doi.org/10.1038/382255a0
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DOI: https://doi.org/10.1038/382255a0
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