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The guinea-pig is not a rodent

Abstract

IN 1991 Graur et al. raised the question of whether the guinea-pig, Cavia porcellus, is a rodent1. They suggested that the guinea-pig and myomorph rodents diverged before the separation between myomorph rodents and a lineage leading to primates and artiodactyls. Several findings have since been reported, both for and against this phylogeny, thereby highlighting the issue of the validity of molecular analysis in mammalian phylogeny. Here we present findings based on the sequence of the complete mitochondrial genome of the guinea-pig, which strongly contradict rodent monophyly. The conclusions are based on the cumulative evidence provided by orthologically inherited genes and the use of three different analytical methods, none of which joins the guinea-pig with myomorph rodents. In addition to the phylogenetic conclusions, we also draw attention to several factors that are important for the validity of phylogenetic analysis based on molecular data.

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References

  1. 1

    Graur, D., Hide, W. A. & Li, W. H. Nature 351, 649–652 (1991).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Li, W. H., Hide, W. A., Zharkikh, A., Ma, D. P. & Graur, D. J. Heredity 83, 174–181 (1992).

    CAS  Article  Google Scholar 

  3. 3

    Graur, D., Hide, W. A., Zharkirkh, A. & Li, W. H. Comp. Biochem. Physiol. 101B, 495–498 (1992).

    CAS  Google Scholar 

  4. 4

    Wolf, B., Reinecke, K., Aumann, K. D., Brigelius-Flohè, R. & Flohè, L. Biol. Chem. Hoppe-Seyler 374, 641–649 (1993).

    CAS  Article  Google Scholar 

  5. 5

    Noguchi, T., Fujiwara, S., Hayashi, S. & Sakuraba, H. Comp. Biochem. Physiol. 107, 179–182 (1994).

    Google Scholar 

  6. 6

    Ma, D. P., Zharkikh, A., Graur, D., VandeBerg, J. L. & Li, W. H. J. molec. Evol. 36, 327–334 (1993).

    ADS  CAS  PubMed  Google Scholar 

  7. 7

    Hasegawa, M., Cao, Y., Adachi, J. & Yano, T. Nature 355, 595 (1992).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Cao, Y., Adachi, J., Yano, T. & Hasegawa, M. Molec. Biol. Evol. 11, 593–604 (1994).

    CAS  PubMed  Google Scholar 

  9. 9

    Kuma, K. & Miyata, T. Jap. J. Genet. 69, 555–566 (1994).

    CAS  Article  Google Scholar 

  10. 10

    Frye, M. S. & Hedges, S. B. Molec. Biol. Evol. 12(1), 168–176 (1995).

    CAS  Article  Google Scholar 

  11. 11

    Martignetti, J. A. & Brosius, J. Proc. natn. Acad. Sci. U.S.A. 90, 9698–9702 (1993).

    ADS  CAS  Article  Google Scholar 

  12. 12

    Novacek, N. J. Nature 356, 121–125 (1992).

    ADS  CAS  Article  Google Scholar 

  13. 13

    Graur, D. FEBS Lett. 325, 152–159 (1993).

    CAS  Article  Google Scholar 

  14. 14

    Graur, D., Duret, L. & Gouy, M. Nature 379, 333–335 (1996).

    ADS  CAS  Article  Google Scholar 

  15. 15

    Swofford, D. L. PAUP: Phylogenetic Analysis Using Parsimony Version 3.1.1 (Illinois Natural History Survey, Champaign, 1993).

    Google Scholar 

  16. 16

    Adachi, J. & Hasegawa, M. MOLPHY: Programs for Molecular Phylogenetics 2.2 (Computer Science Monographs, No. 27, Institute of Statistical Mathematics, Tokyo, 1992).

    Google Scholar 

  17. 17

    Saccone, C., Lanave, C., Pesole, G. & Preparata, G. Meth. Enzym. 183, 570–583 (1990).

    CAS  Article  Google Scholar 

  18. 18

    Irwin, D. M., Kocher, T. D. & Wilson, A. C. J. molec. Evol. 32, 128–144 (1991).

    ADS  CAS  Article  Google Scholar 

  19. 19

    Arnason, U., Gullberg, A. & Widegren, B. J. molec. Evol. 33, 556–568 (1991).

    ADS  CAS  Article  Google Scholar 

  20. 20

    Graur, D. & Higgins, D. G. Molec. Biol. Evol. 11, 357–364 (1994).

    CAS  PubMed  Google Scholar 

  21. 21

    Krettek, A., Gullberg, A. & Arnason, U. J. molec. Evol. 41, 952–957 (1995).

    ADS  CAS  Article  Google Scholar 

  22. 22

    Saitou, N. & Nei, M. Molec. Biol. Evol. 4, 406–425 (1987).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. 23

    Arnason, U., Xu, X. & Gullberg, A. J. molec. Evol. 42, 145–152 (1996).

    ADS  CAS  Article  Google Scholar 

  24. 24

    Arnason, U. & Johnsson, E. J. molec. Evol. 34, 493–505 (1992).

    ADS  CAS  Article  Google Scholar 

  25. 25

    Arnason, U., Gullberg, A., Johnsson, E. & Ledje, C. J. molec. Evol. 37, 323–330 (1993).

    CAS  PubMed  Google Scholar 

  26. 26

    Xu, X. & Arnason, U. Gene 148, 357–362 (1994).

    CAS  Article  Google Scholar 

  27. 27

    Devereux, J., Haeberli, P. & Smithies, O. Nucleic Acids Res. 12, 387–395 (1984).

    CAS  Article  Google Scholar 

  28. 28

    Felsestein, J. PHYLIP (Phytogeny Inference Package), Version 3.5c (University of Washington, Seattle, 1993).

    Google Scholar 

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D'Erchia, A., Gissi, C., Pesole, G. et al. The guinea-pig is not a rodent. Nature 381, 597–600 (1996). https://doi.org/10.1038/381597a0

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