Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

An Erratum to this article was published on 28 November 1996

Abstract

WE report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins1–3. The complex contains transcriptional coactivators and increases the activation of transcription. In addition, some components of the RNA polymerase II complex participate in DNA repair.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Koleske, A. J. & Young, R. A. Nature 368, 466–469 (1994).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Kim, Y.-J., Bjorklund, S., Li, Y., Sayer, M. H. & Kornberg, R. D. Cell 77, 599–608 (1994).

    CAS  Article  Google Scholar 

  3. 3

    Thompson, G. M. & Young, R. A. Proc. natn. Acad. Sci. U.S.A. 92, 4587–4590 (1995).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Seto, E., Shi, Y. & Shenk, T. Nature 354, 241–245 (1991).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Tassan, J.-P., Jaquenoud, M., Leopold, P., Schultz, S. J. & Nigg, E. A. Proc. natn. Acad. Sci. U.S.A. 92, 8871–8875 (1995).

    ADS  CAS  Article  Google Scholar 

  6. 6

    Chao, D. M. et al. Nature 380, 82–85 (1996).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Ge, H. & Roeder, R. G. Cell 78, 513–523 (1994).

    CAS  Article  Google Scholar 

  8. 8

    Kretzschmar, M., Kaiser, K., Lottspeich, F. & Meisterernst, M. Cell 78, 525–534 (1994).

    CAS  Article  Google Scholar 

  9. 9

    Wang, Z. et al. Nature 368, 74–75 (1994).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Drapkin, R. et al. Nature 368, 769–772 (1994).

    ADS  CAS  Article  Google Scholar 

  11. 11

    Van Vuuren, A. J. et al. EMBO J. 13, 1645–1653 (1994).

    CAS  Article  Google Scholar 

  12. 12

    Ivanov, E. L. & Haber, J. E. Molec. cell. Biol. 15, 2245–2251 (1995).

    CAS  Article  Google Scholar 

  13. 13

    Habraken, Y., Sung, P., Prakash, L. & Prakash, S. Nature 371, 531–534 (1994).

    ADS  CAS  Article  Google Scholar 

  14. 14

    Bardwell, A. J., Bardwell, L., Tomkinson, A. E. & Friedberg, E. C. Science 265, 2082–2085 (1994).

    ADS  CAS  Article  Google Scholar 

  15. 15

    Smider, V., Rathmell, W. K., Lieber, M. & Chu, G. Science 266, 288–291 (1994).

    ADS  CAS  Article  Google Scholar 

  16. 16

    Taccioli, G. E. et al. Science 265, 1442–1445 (1994).

    ADS  CAS  Article  Google Scholar 

  17. 17

    Blunt, T. et al. Cell 80, 813–823 (1995).

    CAS  Article  Google Scholar 

  18. 18

    Kirchgessner, U. C. et al. Science 267, 1178–1183 (1995).

    ADS  CAS  Article  Google Scholar 

  19. 19

    Less-Miller, S. P. et al. Science 267, 1183–1185 (1995).

    ADS  Article  Google Scholar 

  20. 20

    Adzuma, K., Ogawa, T. & Ogawa, H. Molec. cell. Biol. 4, 2735–2744 (1984).

    CAS  Article  Google Scholar 

  21. 21

    Shinohara, A., Ogawa, H. & Ogawa, T. Cell 69, 457–470 (1992).

    CAS  Article  Google Scholar 

  22. 22

    Aboussekhra, A., Chanet, R., Adjiri, A. & Fabre, F. Molec. cell. Biol. 12, 3224–3234 (1992).

    CAS  Article  Google Scholar 

  23. 23

    Hwang, P.-I., Chui, G., Asahara, H. & Linn, S. FASEB J. 9, A1398 (1995).

    Google Scholar 

  24. 24

    Nishida, C. P., Reinhard, P. & Linn, S. J. biol. Chem. 263, 501–510 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  25. 25

    Aboussekhra, A. et al. Cell 80, 859–869 (1995).

    CAS  Article  Google Scholar 

  26. 26

    Ossipow et al. Cell 83, 137–146 (1995).

    CAS  Article  Google Scholar 

  27. 27

    Gerard, M. et al. J. biol. Chem. 266, 20940–20945 (1991).

    CAS  PubMed  PubMed Central  Google Scholar 

  28. 28

    Lu, H., Flores, O., Weinmann, R. & Reinberg, D. Proc. natn. Acad. Sci. U.S.A. 88, 10004–10008 (1991).

    ADS  CAS  Article  Google Scholar 

  29. 29

    Flores, O., Maldonado, E. & Reinberg, D. J. biol. Chem. 264, 8913–8921 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  30. 30

    Huang, J. C., Svoboda, D. L., Reardon, J. T. & Sancar, A. Proc. natn. Acad. Sci. U.S.A. 89, 3664–3668 (1992).

    ADS  CAS  Article  Google Scholar 

  31. 31

    Lai, J.-S. & Herr, W. Proc. natn. Acad. Sci. U.S.A. 89, 6958–6962 (1992).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Maldonado, E., Shiekhattar, R., Sheldon, M. et al. A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature 381, 86–89 (1996). https://doi.org/10.1038/381086a0

Download citation

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing