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A human RNA polymerase II complex associated with SRB and DNA-repair proteins

Nature volume 381, pages 86–89 (1996)Cite this article

An Erratum to this article was published on 28 November 1996

Abstract

WE report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins1–3. The complex contains transcriptional coactivators and increases the activation of transcription. In addition, some components of the RNA polymerase II complex participate in DNA repair.

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Author notes

  1. Michael Sheldon

    Present address: Department of Developmental Neurobiology, St Jude Children's Research Hospital, 312 North Lauderdale, Memphis, Tennessee, 38105, USA

  2. Paula Rickert and Emma Lees: DNAX Research Institute of Molecular and Cellular Biology, Department of Chemistry, Stanford University, Palo Alto, California 94304, USA

  3. Carl W. Anderson: Biology Department, Brookhaven National Laboratory, Upton, New York 11973, USA

  4. Stuart Linn: Department of Biochemistry, University of California at Berkeley, California 94720, USA

Authors and Affiliations

  1. Howard Hughes Medical Institute, Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, New Jersey, 08854-5635, USA

    Edio Maldonado, Ramin Shiekhattar, Michael Sheldon, Helen Cho, Ronny Drapkin, Paula Rickert, Emma Lees, Carl W. Anderson, Stuart Linn & Danny Reinberg

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  1. Edio Maldonado
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Maldonado, E., Shiekhattar, R., Sheldon, M. et al. A human RNA polymerase II complex associated with SRB and DNA-repair proteins. Nature 381, 86–89 (1996). https://doi.org/10.1038/381086a0

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